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dc.contributor.authorChaudhury, S
dc.contributor.authorO'Connor, C
dc.contributor.authorCanete, A
dc.contributor.authorBittencourt-Silvestre, J
dc.contributor.authorSarrou, E
dc.contributor.authorPrendergast, A
dc.contributor.authorChoi, J
dc.contributor.authorJohnston, P
dc.contributor.authorWells, CA
dc.contributor.authorGibson, B
dc.contributor.authorKeeshan, K
dc.date.accessioned2020-12-10T00:43:16Z
dc.date.available2020-12-10T00:43:16Z
dc.date.issued2018-12-11
dc.identifierpii: 10.1038/s41467-018-07584-1
dc.identifier.citationChaudhury, S., O'Connor, C., Canete, A., Bittencourt-Silvestre, J., Sarrou, E., Prendergast, A., Choi, J., Johnston, P., Wells, C. A., Gibson, B. & Keeshan, K. (2018). Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-018-07584-1.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/253556
dc.description.abstractAcute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major causes of death in children with cancer and for children with AML relapse is the most common cause of death. Here, by modelling AML in vivo we demonstrate that AML is discriminated by the age of the cell of origin. Young cells give rise to myeloid, lymphoid or mixed phenotype acute leukaemia, whereas adult cells give rise exclusively to AML, with a shorter latency. Unlike adult, young AML cells do not remodel the bone marrow stroma. Transcriptional analysis distinguishes young AML by the upregulation of immune pathways. Analysis of human paediatric AML samples recapitulates a paediatric immune cell interaction gene signature, highlighting two genes, RGS10 and FAM26F as prognostically significant. This work advances our understanding of paediatric AML biology, and provides murine models that offer the potential for developing paediatric specific therapeutic strategies.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAge-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-018-07584-1
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.source.titleNature Communications
melbourne.source.volume9
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1361195
melbourne.contributor.authorChoi, Jarny
melbourne.contributor.authorWells, Christine
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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