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    The involvement of purinergic signalling in obesity

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    Author
    Burnstock, G; Gentile, D
    Date
    2018-06-01
    Source Title
    Purinergic Signalling
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Burnstock, Geoffrey
    Affiliation
    Pharmacology and Therapeutics
    Metadata
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    Document Type
    Journal Article
    Citations
    Burnstock, G. & Gentile, D. (2018). The involvement of purinergic signalling in obesity. PURINERGIC SIGNALLING, 14 (2), pp.97-108. https://doi.org/10.1007/s11302-018-9605-8.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253593
    DOI
    10.1007/s11302-018-9605-8
    Abstract
    Obesity is a growing worldwide health problem, with an alarming increasing prevalence in developed countries, caused by a dysregulation of energy balance. Currently, no wholly successful pharmacological treatments are available for obesity and related adverse consequences. In recent years, hints obtained from several experimental animal models support the notion that purinergic signalling, acting through ATP-gated ion channels (P2X), G protein-coupled receptors (P2Y) and adenosine receptors (P1), is involved in obesity, both at peripheral and central levels. This review has drawn together, for the first time, the evidence for a promising, much needed novel therapeutic purinergic signalling approach for the treatment of obesity with a 'proof of concept' that hopefully could lead to further investigations and clinical trials for the management of obesity.

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