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dc.contributor.authorBurnstock, G
dc.contributor.authorGentile, D
dc.date.accessioned2020-12-10T00:51:39Z
dc.date.available2020-12-10T00:51:39Z
dc.date.issued2018-06-01
dc.identifierpii: 10.1007/s11302-018-9605-8
dc.identifier.citationBurnstock, G. & Gentile, D. (2018). The involvement of purinergic signalling in obesity. PURINERGIC SIGNALLING, 14 (2), pp.97-108. https://doi.org/10.1007/s11302-018-9605-8.
dc.identifier.issn1573-9538
dc.identifier.urihttp://hdl.handle.net/11343/253593
dc.description.abstractObesity is a growing worldwide health problem, with an alarming increasing prevalence in developed countries, caused by a dysregulation of energy balance. Currently, no wholly successful pharmacological treatments are available for obesity and related adverse consequences. In recent years, hints obtained from several experimental animal models support the notion that purinergic signalling, acting through ATP-gated ion channels (P2X), G protein-coupled receptors (P2Y) and adenosine receptors (P1), is involved in obesity, both at peripheral and central levels. This review has drawn together, for the first time, the evidence for a promising, much needed novel therapeutic purinergic signalling approach for the treatment of obesity with a 'proof of concept' that hopefully could lead to further investigations and clinical trials for the management of obesity.
dc.languageEnglish
dc.publisherSPRINGER
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe involvement of purinergic signalling in obesity
dc.typeJournal Article
dc.identifier.doi10.1007/s11302-018-9605-8
melbourne.affiliation.departmentPharmacology and Therapeutics
melbourne.source.titlePurinergic Signalling
melbourne.source.volume14
melbourne.source.issue2
melbourne.source.pages97-108
dc.rights.licenseCC BY
melbourne.elementsid1323098
melbourne.contributor.authorBurnstock, Geoffrey
dc.identifier.eissn1573-9546
melbourne.accessrightsOpen Access


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