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dc.contributor.authorNg, SP
dc.contributor.authorTan, J
dc.contributor.authorOsbourne, G
dc.contributor.authorWilliams, L
dc.contributor.authorBressel, MAB
dc.contributor.authorHicks, RJ
dc.contributor.authorLau, EWF
dc.contributor.authorChu, J
dc.contributor.authorNgan, SYK
dc.contributor.authorLeong, T
dc.date.accessioned2020-12-10T00:51:54Z
dc.date.available2020-12-10T00:51:54Z
dc.date.issued2017-02-01
dc.identifierpii: S2405-6308(16)30045-3
dc.identifier.citationNg, S. P., Tan, J., Osbourne, G., Williams, L., Bressel, M. A. B., Hicks, R. J., Lau, E. W. F., Chu, J., Ngan, S. Y. K. & Leong, T. (2017). Follow up results of a prospective study to evaluate the impact of FDG-PET on CT-based radiotherapy treatment planning for oesophageal cancer. CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY, 2, pp.76-82. https://doi.org/10.1016/j.ctro.2017.01.008.
dc.identifier.issn2405-6308
dc.identifier.urihttp://hdl.handle.net/11343/253594
dc.description.abstractBackground: This prospective study aims to determine the impact of PET/CT on radiotherapy planning and outcomes in patients with oesophageal cancer. Methods: All patients underwent PET/CT scanning in the radiotherapy treatment position, and received treatment planned using the PET/CT dataset. GTV was defined separately on PET/CT (GTV-PET) and CT (GTV-CT) datasets. A corresponding PTV was generated for each patient. Volumetric and spatial analysis quantified the proportion of FDG-avid disease not included in CT-based volumes. Clinical data was collected to determine locoregional control and overall survival rates. Results: 13 (24.1%) of 57 accrued patients had metastatic disease detected on PET. Median follow up was 4 years. FDG-avid disease would have been excluded from GTV-CT in 29 of 38 patients (76%). In 5 patients, FDG-avid disease would have been completely excluded from the PTV-CT. GTV-CT underestimated the cranial and caudal extent of FDG-avid tumour in 14 (36%) and 10 (26%) patients. 4-Year overall survival and locoregional failure free survival were 37% and 65%. Conclusions: PET/CT altered the delineation of tumour volumes when compared to CT alone, and should be considered standard for treatment planning. Although clinical outcomes were not improved with PET/CT planning, it did allow the use of smaller radiotherapy volumes.
dc.languageEnglish
dc.publisherELSEVIER IRELAND LTD
dc.titleFollow up results of a prospective study to evaluate the impact of FDG-PET on CT-based radiotherapy treatment planning for oesophageal cancer
dc.typeJournal Article
dc.identifier.doi10.1016/j.ctro.2017.01.008
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.department
melbourne.source.titleClinical and Translational Radiation Oncology
melbourne.source.volume2
melbourne.source.pages76-82
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1323189
melbourne.contributor.authorLeong, Trevor
melbourne.contributor.authorNgan, Samuel
melbourne.contributor.authorHicks, Rodney
melbourne.contributor.authorLau, Wing
melbourne.contributor.authorNg, Sweet
dc.identifier.eissn2405-6308
melbourne.accessrightsOpen Access


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