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dc.contributor.authorNg, SS
dc.contributor.authorSouza-Fonseca-Guimaraes, F
dc.contributor.authorRivera, FDL
dc.contributor.authorAmante, FH
dc.contributor.authorKumar, R
dc.contributor.authorGao, Y
dc.contributor.authorSheel, M
dc.contributor.authorBeattie, L
dc.contributor.authorde Oca, MM
dc.contributor.authorGuillerey, C
dc.contributor.authorEdwards, CL
dc.contributor.authorFaleiro, RJ
dc.contributor.authorFrame, T
dc.contributor.authorBunn, PT
dc.contributor.authorVivier, E
dc.contributor.authorGodfrey, DI
dc.contributor.authorPellicci, DG
dc.contributor.authorLopez, JA
dc.contributor.authorAndrews, KT
dc.contributor.authorHuntington, ND
dc.contributor.authorSmyth, MJ
dc.contributor.authorMcCarthy, J
dc.contributor.authorEngwerda, CR
dc.date.accessioned2020-12-10T00:54:06Z
dc.date.available2020-12-10T00:54:06Z
dc.date.issued2018-01-12
dc.identifierpii: CTI21003
dc.identifier.citationNg, S. S., Souza-Fonseca-Guimaraes, F., Rivera, F. D. L., Amante, F. H., Kumar, R., Gao, Y., Sheel, M., Beattie, L., de Oca, M. M., Guillerey, C., Edwards, C. L., Faleiro, R. J., Frame, T., Bunn, P. T., Vivier, E., Godfrey, D. I., Pellicci, D. G., Lopez, J. A., Andrews, K. T. ,... Engwerda, C. R. (2018). Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 7 (1), https://doi.org/10.1002/cti2.1003.
dc.identifier.issn2050-0068
dc.identifier.urihttp://hdl.handle.net/11343/253602
dc.description.abstractObjectives: Innate lymphoid cells (ILCs) share many characteristics with CD4+ T cells, and group 1 ILCs share a requirement for T-bet and the ability to produce IFNγ with T helper 1 (Th1) cells. Given this similarity, and the importance of Th1 cells for protection against intracellular protozoan parasites, we aimed to characterise the role of group 1 ILCs during Plasmodium infection. Methods: We quantified group 1 ILCs in peripheral blood collected from subjects infected with with Plasmodium falciparum 3D7 as part of a controlled human malaria infection study, and in the liver and spleens of Pc AS-infected mice. We used genetically-modified mouse models, as well as cell-depletion methods in mice to characterise the role of group 1 ILCs during Pc AS infection. Results: In a controlled human malaria infection study, we found that the frequencies of circulating ILC1s and NK cells decreased as infection progressed but recovered after volunteers were treated with antiparasitic drug. A similar observation was made for liver and splenic ILC1s in P. chabaudi chabaudi AS (Pc AS)-infected mice. The decrease in mouse liver ILC1 frequencies was associated with increased apoptosis. We also identified a population of cells within the liver and spleen that expressed both ILC1 and NK cell markers, indicative of plasticity between these two cell lineages. Studies using genetic and cell-depletion approaches indicated that group 1 ILCs have a limited role in antiparasitic immunity during Pc AS infection in mice. Discussion: Our results are consistent with a previous study indicating a limited role for natural killer (NK) cells during Plasmodium chabaudi infection in mice. Additionally, a recent study reported the redundancy of ILCs in humans with competent B and T cells. Nonetheless, our results do not rule out a role for group 1 ILCs in human malaria in endemic settings given that blood stage infection was initiated intravenously in our experimental models, and thus bypassed the liver stage of infection, which may influence the immune response during the blood stage. Conclusion: Our results show that ILC1s are lost early during mouse and human malaria, and this observation may help to explain the limited role for these cells in controlling blood stage infection.
dc.languageEnglish
dc.publisherWILEY
dc.titleRapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection
dc.typeJournal Article
dc.identifier.doi10.1002/cti2.1003
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleClinical and Translational Immunology
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1323466
melbourne.contributor.authorHuntington, Nicholas
melbourne.contributor.authorGodfrey, Dale
melbourne.contributor.authorPellicci, Daniel
melbourne.contributor.authorBeattie, Lynette
melbourne.contributor.authorFonseca Guimaraes, Fernando
dc.identifier.eissn2050-0068
melbourne.accessrightsOpen Access


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