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dc.contributor.authorYang, H
dc.contributor.authorYoung, D
dc.contributor.authorGao, J
dc.contributor.authorYuan, Y
dc.contributor.authorShen, M
dc.contributor.authorZhang, Y
dc.contributor.authorDuan, X
dc.contributor.authorZhu, S
dc.contributor.authorSun, X
dc.date.accessioned2020-12-10T00:55:02Z
dc.date.available2020-12-10T00:55:02Z
dc.date.issued2019-01-18
dc.identifierpii: 10.1186/s12944-019-0970-2
dc.identifier.citationYang, H., Young, D., Gao, J., Yuan, Y., Shen, M., Zhang, Y., Duan, X., Zhu, S. & Sun, X. (2019). Are blood lipids associated with microvascular complications among type 2 diabetes mellitus patients? A cross-sectional study in Shanghai, China. LIPIDS IN HEALTH AND DISEASE, 18 (1), https://doi.org/10.1186/s12944-019-0970-2.
dc.identifier.issn1476-511X
dc.identifier.urihttp://hdl.handle.net/11343/253606
dc.description.abstractBACKGROUND: Although there are several studies to investigate the association between blood lipids and microvascular complications, these studies reported conflicting results. The aim of the current study was to explore the association between blood lipid parameters and the risk of microvascular complications, especially the dose-response association between them, among community patients with type 2 diabetes mellitus (T2DM) in Shanghai, China. METHODS: The cross-sectional study was conducted in 6 community health service centers in Shanghai between December 2014 and December 2016.The associations between blood lipids and diabetic kidney disease (DKD) or diabetic retinopathy (DR) were assessed using multiple logistic regression. Restricted cubic spline (RCS) was employed to estimate the dose-response relation of blood lipids and the risk of microvascular complications. RESULTS: A total of 3698 participants were included in the final analysis to study the association between blood lipids and DKD, wherein 33.2% of participants had DKD and 1374 were included for the analysis of the association between blood lipids and DR, wherein 23.2% of participants had DR. DKD odds ratio was increased by 1.16(95%CI,1.08-1.25), 1.21(95%CI,1.13-1.30), 1.18(95%CI,1.10-1.26) for comparing fourth to first quartiles of triglycerides (TG), TG/high-density lipoprotein cholesterol (HDL-C), non-HDL-C/HDL-C, respectively, and decreased by 0.83(95%CI,0.78-0.89) for comparing fourth to first quartiles of HDL-C. Furthermore, the dose-response association between TG, HDL-C, TG/HDL-C, non-HDL-C/HDL-C and the risk of DKD demonstrated turning points in TG of 1.90 mmol/L, HDL-C of 1.62 mmol/L, TG/HDL-C of 2.00, non-HDL-C/HDL-C of 3.09, respectively. However, no significant association was found between blood lipid parameters and DR. CONCLUSIONS: This community-based study indicated that TG, HDL-C, TG/HDL-C, non-HDL-C/HDL-C were independently associated with DKD but not DR.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAre blood lipids associated with microvascular complications among type 2 diabetes mellitus patients? A cross-sectional study in Shanghai, China
dc.typeJournal Article
dc.identifier.doi10.1186/s12944-019-0970-2
melbourne.affiliation.departmentGeneral Practice
melbourne.source.titleLipids in Health and Disease
melbourne.source.volume18
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1369175
melbourne.contributor.authorYoung, Doris
dc.identifier.eissn1476-511X
melbourne.accessrightsOpen Access


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