The Sybtraps: control of synaptobrevin traffic by synaptophysin, α-synuclein and AP-180.

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Author
Gordon, SL; Cousin, MADate
2014-03Source Title
TrafficPublisher
WileyUniversity of Melbourne Author/s
Gordon, SarahAffiliation
Florey Department of Neuroscience and Mental HealthMetadata
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Journal ArticleCitations
Gordon, S. L. & Cousin, M. A. (2014). The Sybtraps: control of synaptobrevin traffic by synaptophysin, α-synuclein and AP-180.. Traffic, 15 (3), pp.245-254. https://doi.org/10.1111/tra.12140.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992847Abstract
Synaptobrevin II (sybII) is a key fusogenic molecule on synaptic vesicles (SVs) therefore the active maintenance of both its conformation and location in sufficient numbers on this organelle is critical in both mediating and sustaining neurotransmitter release. Recently three proteins have been identified having key roles in the presentation, trafficking and retrieval of sybII during the fusion and endocytosis of SVs. The nerve terminal protein α-synuclein catalyses sybII entry into SNARE complexes, whereas the monomeric adaptor protein AP-180 is required for sybII retrieval during SV endocytosis. Overarching these events is the tetraspan SV protein synaptophysin, which is a major sybII interaction partner on the SV. This review will evaluate recent studies to propose working models for the control of sybII traffic by synaptophysin and other Sybtraps (sybII trafficking partners) and suggest how dysfunction in sybII traffic may contribute to human disease.
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