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  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
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    The Sybtraps: control of synaptobrevin traffic by synaptophysin, α-synuclein and AP-180.

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    Author
    Gordon, SL; Cousin, MA
    Date
    2014-03
    Source Title
    Traffic
    Publisher
    Wiley
    University of Melbourne Author/s
    Gordon, Sarah
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Gordon, S. L. & Cousin, M. A. (2014). The Sybtraps: control of synaptobrevin traffic by synaptophysin, α-synuclein and AP-180.. Traffic, 15 (3), pp.245-254. https://doi.org/10.1111/tra.12140.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253609
    DOI
    10.1111/tra.12140
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992847
    Abstract
    Synaptobrevin II (sybII) is a key fusogenic molecule on synaptic vesicles (SVs) therefore the active maintenance of both its conformation and location in sufficient numbers on this organelle is critical in both mediating and sustaining neurotransmitter release. Recently three proteins have been identified having key roles in the presentation, trafficking and retrieval of sybII during the fusion and endocytosis of SVs. The nerve terminal protein α-synuclein catalyses sybII entry into SNARE complexes, whereas the monomeric adaptor protein AP-180 is required for sybII retrieval during SV endocytosis. Overarching these events is the tetraspan SV protein synaptophysin, which is a major sybII interaction partner on the SV. This review will evaluate recent studies to propose working models for the control of sybII traffic by synaptophysin and other Sybtraps (sybII trafficking partners) and suggest how dysfunction in sybII traffic may contribute to human disease.

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