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dc.contributor.authorLiu, E
dc.contributor.authorKaidonis, G
dc.contributor.authorGillies, MC
dc.contributor.authorAbhary, S
dc.contributor.authorEssex, RW
dc.contributor.authorChang, JH
dc.contributor.authorPal, B
dc.contributor.authorDaniell, M
dc.contributor.authorLake, S
dc.contributor.authorGilhotra, J
dc.contributor.authorPetrovsky, N
dc.contributor.authorHewitt, AW
dc.contributor.authorJenkins, A
dc.contributor.authorLamoureux, EL
dc.contributor.authorGleadle, JM
dc.contributor.authorBurdon, KP
dc.contributor.authorCraig, JE
dc.date.accessioned2020-12-10T00:56:07Z
dc.date.available2020-12-10T00:56:07Z
dc.date.issued2019-01-24
dc.identifierpii: 10.1038/s41598-018-37388-8
dc.identifier.citationLiu, E., Kaidonis, G., Gillies, M. C., Abhary, S., Essex, R. W., Chang, J. H., Pal, B., Daniell, M., Lake, S., Gilhotra, J., Petrovsky, N., Hewitt, A. W., Jenkins, A., Lamoureux, E. L., Gleadle, J. M., Burdon, K. P. & Craig, J. E. (2019). Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample. SCIENTIFIC REPORTS, 9 (1), https://doi.org/10.1038/s41598-018-37388-8.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/253612
dc.description.abstractMitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleMitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-018-37388-8
melbourne.affiliation.departmentCentre for Eye Research Australia (CERA)
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.affiliation.departmentMedicine and Radiology
melbourne.source.titleScientific Reports
melbourne.source.volume9
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1369506
melbourne.contributor.authorLamoureux, Ecosse
melbourne.contributor.authorDaniell, Mark
melbourne.contributor.authorJenkins, Alicia
melbourne.contributor.authorCraig, Jamie
melbourne.contributor.authorHewitt, Alexander
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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