Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia

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    Author
    Slot, RER; Sikkes, SAM; Berkhof, J; Brodaty, H; Buckley, R; Cavedo, E; Dardiotis, E; Guillo-Benarous, F; Hampel, H; Kochan, NA; ...
    Date
    2019-03-01
    Source Title
    Alzheimer's and Dementia
    Publisher
    WILEY
    University of Melbourne Author/s
    Buckley, Rachel; Maruff, Paul
    Affiliation
    Anatomy and Neuroscience
    Melbourne School of Psychological Sciences
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    Document Type
    Journal Article
    Citations
    Slot, R. E. R., Sikkes, S. A. M., Berkhof, J., Brodaty, H., Buckley, R., Cavedo, E., Dardiotis, E., Guillo-Benarous, F., Hampel, H., Kochan, N. A., Lista, S., Luck, T., Maruff, P., Molinuevo, J. L., Kornhuber, J., Reisberg, B., Riedel-Heller, S. G., Risacher, S. L., Roehr, S. ,... van der Flier, W. M. (2019). Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. ALZHEIMERS & DEMENTIA, 15 (3), pp.465-476. https://doi.org/10.1016/j.jalz.2018.10.003.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253618
    DOI
    10.1016/j.jalz.2018.10.003
    Abstract
    INTRODUCTION: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. METHODS: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. RESULTS: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. DISCUSSION: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.

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