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dc.contributor.authorSlot, RER
dc.contributor.authorSikkes, SAM
dc.contributor.authorBerkhof, J
dc.contributor.authorBrodaty, H
dc.contributor.authorBuckley, R
dc.contributor.authorCavedo, E
dc.contributor.authorDardiotis, E
dc.contributor.authorGuillo-Benarous, F
dc.contributor.authorHampel, H
dc.contributor.authorKochan, NA
dc.contributor.authorLista, S
dc.contributor.authorLuck, T
dc.contributor.authorMaruff, P
dc.contributor.authorMolinuevo, JL
dc.contributor.authorKornhuber, J
dc.contributor.authorReisberg, B
dc.contributor.authorRiedel-Heller, SG
dc.contributor.authorRisacher, SL
dc.contributor.authorRoehr, S
dc.contributor.authorSachdev, PS
dc.contributor.authorScarmeas, N
dc.contributor.authorScheltens, P
dc.contributor.authorShulman, MB
dc.contributor.authorSaykin, AJ
dc.contributor.authorVerfaillie, SCJ
dc.contributor.authorVisser, PJ
dc.contributor.authorVos, SJB
dc.contributor.authorWagner, M
dc.contributor.authorWolfsgruber, S
dc.contributor.authorJessen, F
dc.contributor.authorvan der Flier, WM
dc.date.accessioned2020-12-10T00:57:14Z
dc.date.available2020-12-10T00:57:14Z
dc.date.issued2019-03-01
dc.identifierpii: S1552-5260(18)33563-5
dc.identifier.citationSlot, R. E. R., Sikkes, S. A. M., Berkhof, J., Brodaty, H., Buckley, R., Cavedo, E., Dardiotis, E., Guillo-Benarous, F., Hampel, H., Kochan, N. A., Lista, S., Luck, T., Maruff, P., Molinuevo, J. L., Kornhuber, J., Reisberg, B., Riedel-Heller, S. G., Risacher, S. L., Roehr, S. ,... van der Flier, W. M. (2019). Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. ALZHEIMERS & DEMENTIA, 15 (3), pp.465-476. https://doi.org/10.1016/j.jalz.2018.10.003.
dc.identifier.issn1552-5260
dc.identifier.urihttp://hdl.handle.net/11343/253618
dc.description.abstractINTRODUCTION: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. METHODS: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. RESULTS: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. DISCUSSION: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleSubjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia
dc.typeJournal Article
dc.identifier.doi10.1016/j.jalz.2018.10.003
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentMelbourne School of Psychological Sciences
melbourne.source.titleAlzheimer's and Dementia
melbourne.source.volume15
melbourne.source.issue3
melbourne.source.pages465-476
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1361202
melbourne.contributor.authorBuckley, Rachel
melbourne.contributor.authorMaruff, Paul
dc.identifier.eissn1552-5279
melbourne.accessrightsOpen Access


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