A Divergent Hepatitis D-Like Agent in Birds

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    Author
    Wille, M; Netter, HJ; Littlejohn, M; Yuen, L; Shi, M; Eden, J-S; Klaassen, M; Holmes, EC; Hurt, AC
    Date
    2018-12-01
    Source Title
    Viruses
    Publisher
    MDPI
    University of Melbourne Author/s
    Littlejohn, Margaret; Hurt, Aeron
    Affiliation
    Melbourne School of Population and Global Health
    Doherty Institute
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Wille, M., Netter, H. J., Littlejohn, M., Yuen, L., Shi, M., Eden, J. -S., Klaassen, M., Holmes, E. C. & Hurt, A. C. (2018). A Divergent Hepatitis D-Like Agent in Birds. VIRUSES-BASEL, 10 (12), https://doi.org/10.3390/v10120720.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253624
    DOI
    10.3390/v10120720
    Abstract
    Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents.

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