A Divergent Hepatitis D-Like Agent in Birds
AuthorWille, M; Netter, HJ; Littlejohn, M; Yuen, L; Shi, M; Eden, J-S; Klaassen, M; Holmes, EC; Hurt, AC
AffiliationMelbourne School of Population and Global Health
Document TypeJournal Article
CitationsWille, M., Netter, H. J., Littlejohn, M., Yuen, L., Shi, M., Eden, J. -S., Klaassen, M., Holmes, E. C. & Hurt, A. C. (2018). A Divergent Hepatitis D-Like Agent in Birds. VIRUSES-BASEL, 10 (12), https://doi.org/10.3390/v10120720.
Access StatusOpen Access
Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents.
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