Nephron progenitor commitment is a stochastic process influenced by cell migration
AuthorLawlor, KT; Zappia, L; Lefevre, J; Park, J-S; Hamilton, NA; Oshlack, A; Little, MH; Combes, AN
PublisherELIFE SCIENCES PUBLICATIONS LTD
University of Melbourne Author/sCombes, Alexander; Lawlor, Kynan; Oshlack, Alicia; Little, Melissa; Zappia, Luke
AffiliationSchool of Physics
Anatomy and Neuroscience
Document TypeJournal Article
CitationsLawlor, K. T., Zappia, L., Lefevre, J., Park, J. -S., Hamilton, N. A., Oshlack, A., Little, M. H. & Combes, A. N. (2019). Nephron progenitor commitment is a stochastic process influenced by cell migration. ELIFE, 8, https://doi.org/10.7554/eLife.41156.
Access StatusOpen Access
ARC Grant codeARC/DE150100652
Progenitor self-renewal and differentiation is often regulated by spatially restricted cues within a tissue microenvironment. Here, we examine how progenitor cell migration impacts regionally induced commitment within the nephrogenic niche in mice. We identify a subset of cells that express Wnt4, an early marker of nephron commitment, but migrate back into the progenitor population where they accumulate over time. Single cell RNA-seq and computational modelling of returning cells reveals that nephron progenitors can traverse the transcriptional hierarchy between self-renewal and commitment in either direction. This plasticity may enable robust regulation of nephrogenesis as niches remodel and grow during organogenesis.
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