The Influence of Aerobic Exercise on Hippocampal Integrity and Function: Preliminary Findings of a Multi-Modal Imaging Analysis.

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    Author
    Den Ouden, L; Kandola, A; Suo, C; Hendrikse, J; Costa, RJS; Watt, MJ; Lorenzetti, V; Chye, Y; Parkes, L; Sabaroedin, K; ...
    Date
    2018-12-26
    Source Title
    Brain Plasticity
    Publisher
    IOS Press
    University of Melbourne Author/s
    Watt, Matthew
    Affiliation
    Physiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Den Ouden, L., Kandola, A., Suo, C., Hendrikse, J., Costa, R. J. S., Watt, M. J., Lorenzetti, V., Chye, Y., Parkes, L., Sabaroedin, K. & Yücel, M. (2018). The Influence of Aerobic Exercise on Hippocampal Integrity and Function: Preliminary Findings of a Multi-Modal Imaging Analysis.. Brain Plast, 4 (2), pp.211-216. https://doi.org/10.3233/BPL-170053.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253669
    DOI
    10.3233/BPL-170053
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311350
    Abstract
    Aerobic exercise (AE) interventions represent promising therapeutic approaches in disorders that compromise hippocampal integrity, but a more comprehensive account of the neural mechanisms stimulated by AE in the human brain is needed. We conducted a longitudinal pilot-study to assess the impact of a 12-week AE intervention on hippocampal structure and function in 10 healthy, human participants (50% females; 25-59 years). Using a novel combination of multimodal MRI techniques, we found significant increases in left hippocampal volume, Cornu Ammonis subfield area 1, NAA concentration and immediate verbal recall performance. Our preliminary findings highlight the utility of a multimodal approach in assessing hippocampal integrity.

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