Current perspectives in Set7 mediated stem cell differentiation.

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    Author
    Karimnia, N; Rafehi, H; Tuano, NK; Ziemann, M; K N, H; Okabe, J; El-Osta, A
    Date
    2016-12-04
    Source Title
    Non-Coding RNA
    Publisher
    MDPI AG
    University of Melbourne Author/s
    El-Osta, Assam
    Affiliation
    Clinical Pathology
    Metadata
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    Document Type
    Journal Article
    Citations
    Karimnia, N., Rafehi, H., Tuano, N. K., Ziemann, M., K N, H., Okabe, J. & El-Osta, A. (2016). Current perspectives in Set7 mediated stem cell differentiation.. Noncoding RNA, 2 (4), pp.14-14. https://doi.org/10.3390/ncrna2040014.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253679
    DOI
    10.3390/ncrna2040014
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831927
    Abstract
    Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.

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