Current perspectives in Set7 mediated stem cell differentiation.
AuthorKarimnia, N; Rafehi, H; Tuano, NK; Ziemann, M; K N, H; Okabe, J; El-Osta, A
Source TitleNon-Coding RNA
University of Melbourne Author/sEl-Osta, Assam
Document TypeJournal Article
CitationsKarimnia, N., Rafehi, H., Tuano, N. K., Ziemann, M., K N, H., Okabe, J. & El-Osta, A. (2016). Current perspectives in Set7 mediated stem cell differentiation.. Noncoding RNA, 2 (4), pp.14-14. https://doi.org/10.3390/ncrna2040014.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831927
Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.
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