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    RNA interference for the treatment of papillomavirus disease.

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    Author
    Singhania, R; Khairuddin, N; Clarke, D; McMillan, NA
    Date
    2012
    Source Title
    Open Virology Journal
    Publisher
    Bentham Science Publishers Ltd.
    University of Melbourne Author/s
    Clarke, Daniel
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Singhania, R., Khairuddin, N., Clarke, D. & McMillan, N. A. (2012). RNA interference for the treatment of papillomavirus disease.. Open Virol J, 6 (1), pp.204-215. https://doi.org/10.2174/1874357901206010204.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253700
    DOI
    10.2174/1874357901206010204
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547394
    Abstract
    Human Papillomavirus (HPV)-induced diseases are a significant burden on our healthcare system and current therapies are not curative. Vaccination provides significant prophylactic protection but effective therapeutic treatments will still be required. RNA interference (RNAi) has great promise in providing highly specific therapies for all HPV diseases yet this promise has not been realised. Here we review the research into RNAi therapy for HPV in vitro and in vivo and examine the various targets and outcomes. We discuss the idea of using RNAi with current treatments and address delivery of RNAi, the major issue holding back clinical adoption. Finally, we present our view of a potential path to the clinic.

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