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    Influenza Virus Neuraminidase Structure and Functions

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    Author
    McAuley, JL; Gilbertson, BP; Trifkovic, S; Brown, LE; McKimm-Breschkin, JL
    Date
    2019-01-29
    Source Title
    Frontiers in Microbiology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Brown, Lorena; Gilbertson, Bradley; McAuley, Julie; McKimm-Breschkin, Jennifer; Trifkovic, Sanja
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    McAuley, J. L., Gilbertson, B. P., Trifkovic, S., Brown, L. E. & McKimm-Breschkin, J. L. (2019). Influenza Virus Neuraminidase Structure and Functions. FRONTIERS IN MICROBIOLOGY, 10 (JAN), https://doi.org/10.3389/fmicb.2019.00039.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253707
    DOI
    10.3389/fmicb.2019.00039
    Abstract
    With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence. Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness. This review investigates the various structural features of NA, linking these with functional outcomes in viral replication. The contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance with the viral hemagglutinin are also discussed. Greater insight into the role of this important antiviral drug target is warranted.

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