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dc.contributor.authorMcAuley, JL
dc.contributor.authorGilbertson, BP
dc.contributor.authorTrifkovic, S
dc.contributor.authorBrown, LE
dc.contributor.authorMcKimm-Breschkin, JL
dc.date.accessioned2020-12-10T01:26:41Z
dc.date.available2020-12-10T01:26:41Z
dc.date.issued2019-01-29
dc.identifier.citationMcAuley, J. L., Gilbertson, B. P., Trifkovic, S., Brown, L. E. & McKimm-Breschkin, J. L. (2019). Influenza Virus Neuraminidase Structure and Functions. FRONTIERS IN MICROBIOLOGY, 10 (JAN), https://doi.org/10.3389/fmicb.2019.00039.
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/11343/253707
dc.description.abstractWith the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence. Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness. This review investigates the various structural features of NA, linking these with functional outcomes in viral replication. The contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance with the viral hemagglutinin are also discussed. Greater insight into the role of this important antiviral drug target is warranted.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.titleInfluenza Virus Neuraminidase Structure and Functions
dc.typeJournal Article
dc.identifier.doi10.3389/fmicb.2019.00039
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleFrontiers in Microbiology
melbourne.source.volume10
melbourne.source.issueJAN
dc.rights.licenseCC BY
melbourne.elementsid1371931
melbourne.contributor.authorBrown, Lorena
melbourne.contributor.authorGilbertson, Bradley
melbourne.contributor.authorMcAuley, Julie
melbourne.contributor.authorMcKimm-Breschkin, Jennifer
melbourne.contributor.authorTrifkovic, Sanja
dc.identifier.eissn1664-302X
melbourne.accessrightsOpen Access


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