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    Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.

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    Author
    Vijayakrishnan, J; Studd, J; Broderick, P; Kinnersley, B; Holroyd, A; Law, PJ; Kumar, R; Allan, JM; Harrison, CJ; Moorman, AV; ...
    Date
    2018-04-09
    Source Title
    Nature Communications
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Giles, Graham
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Vijayakrishnan, J., Studd, J., Broderick, P., Kinnersley, B., Holroyd, A., Law, P. J., Kumar, R., Allan, J. M., Harrison, C. J., Moorman, A. V., Vora, A., Roman, E., Rachakonda, S., Kinsey, S. E., Sheridan, E., Thompson, P. D., Irving, J. A., Koehler, R., Hoffmann, P. ,... Houlston, R. S. (2018). Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.. Nat Commun, 9 (1), pp.1340-. https://doi.org/10.1038/s41467-018-03178-z.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253713
    DOI
    10.1038/s41467-018-03178-z
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890276
    Abstract
    Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.

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