Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
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Date
2018-04-09Source Title
Nature CommunicationsPublisher
Springer Science and Business Media LLCAffiliation
Melbourne School of Population and Global HealthMetadata
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Journal ArticleCitations
Vijayakrishnan, J., Studd, J., Broderick, P., Kinnersley, B., Holroyd, A., Law, P. J., Kumar, R., Allan, J. M., Harrison, C. J., Moorman, A. V., Vora, A., Roman, E., Rachakonda, S., Kinsey, S. E., Sheridan, E., Thompson, P. D., Irving, J. A., Koehler, R., Hoffmann, P. ,... Houlston, R. S. (2018). Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.. Nat Commun, 9 (1), pp.1340-. https://doi.org/10.1038/s41467-018-03178-z.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890276Abstract
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
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