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dc.contributor.authorHorne, HN
dc.contributor.authorOh, H
dc.contributor.authorSherman, ME
dc.contributor.authorPalakal, M
dc.contributor.authorHewitt, SM
dc.contributor.authorSchmidt, MK
dc.contributor.authorMilne, RL
dc.contributor.authorHardisson, D
dc.contributor.authorBenitez, J
dc.contributor.authorBlomqvist, C
dc.contributor.authorBolla, MK
dc.contributor.authorBrenner, H
dc.contributor.authorChang-Claude, J
dc.contributor.authorCora, R
dc.contributor.authorCouch, FJ
dc.contributor.authorCuk, K
dc.contributor.authorDevilee, P
dc.contributor.authorEaston, DF
dc.contributor.authorEccles, DM
dc.contributor.authorEilber, U
dc.contributor.authorHartikainen, JM
dc.contributor.authorHeikkila, P
dc.contributor.authorHolleczek, B
dc.contributor.authorHooning, MJ
dc.contributor.authorJones, M
dc.contributor.authorKeeman, R
dc.contributor.authorMannermaa, A
dc.contributor.authorMartens, JWM
dc.contributor.authorMuranen, TA
dc.contributor.authorNevanlinna, H
dc.contributor.authorOlson, JE
dc.contributor.authorOrr, N
dc.contributor.authorPerez, JIA
dc.contributor.authorPharoah, PDP
dc.contributor.authorRuddy, KJ
dc.contributor.authorSaum, K-U
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorSeynaeve, C
dc.contributor.authorSironen, R
dc.contributor.authorSmit, VTHBM
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTengstrom, M
dc.contributor.authorThomas, AS
dc.contributor.authorTimmermans, AM
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTroester, MA
dc.contributor.authorvan Asperen, CJ
dc.contributor.authorvan Deurzen, CHM
dc.contributor.authorVan Leeuwen, FF
dc.contributor.authorVan'tVeer, LJ
dc.contributor.authorGarcia-Closas, M
dc.contributor.authorFigueroa, JD
dc.date.accessioned2020-12-10T01:30:37Z
dc.date.available2020-12-10T01:30:37Z
dc.date.issued2018-04-26
dc.identifierpii: 10.1038/s41598-018-23733-4
dc.identifier.citationHorne, H. N., Oh, H., Sherman, M. E., Palakal, M., Hewitt, S. M., Schmidt, M. K., Milne, R. L., Hardisson, D., Benitez, J., Blomqvist, C., Bolla, M. K., Brenner, H., Chang-Claude, J., Cora, R., Couch, F. J., Cuk, K., Devilee, P., Easton, D. F., Eccles, D. M. ,... Figueroa, J. D. (2018). E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. SCIENTIFIC REPORTS, 8 (1), https://doi.org/10.1038/s41598-018-23733-4.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/253723
dc.description.abstractE-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleE-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-018-23733-4
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleScientific Reports
melbourne.source.volume8
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1325559
melbourne.contributor.authorMilne, Roger
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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