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dc.contributor.authorvan Houwelingen, KG
dc.contributor.authorvan der Heijden, LC
dc.contributor.authorLam, MK
dc.contributor.authorKok, MM
dc.contributor.authorLowik, MM
dc.contributor.authorLouwerenburg, JW
dc.contributor.authorLinssen, GCM
dc.contributor.authorIJzerman, MJ
dc.contributor.authorDoggen, CJM
dc.contributor.authorvon Birgelen, C
dc.date.accessioned2020-12-10T01:32:33Z
dc.date.available2020-12-10T01:32:33Z
dc.date.issued2016-11-01
dc.identifierpii: 10.1007/s00380-015-0786-6
dc.identifier.citationvan Houwelingen, K. G., van der Heijden, L. C., Lam, M. K., Kok, M. M., Lowik, M. M., Louwerenburg, J. W., Linssen, G. C. M., IJzerman, M. J., Doggen, C. J. M. & von Birgelen, C. (2016). Long-term outcome and chest pain in patients with true versus non-true bifurcation lesions treated with second-generation drug-eluting stents in the TWENTE trial. HEART AND VESSELS, 31 (11), pp.1731-1739. https://doi.org/10.1007/s00380-015-0786-6.
dc.identifier.issn0910-8327
dc.identifier.urihttp://hdl.handle.net/11343/253730
dc.description.abstractThe objective of this study is to assess 3-year clinical outcome of patients with true bifurcation lesions (TBLs) versus non-true bifurcation lesions (non-TBLs) following treatment with second-generation drug-eluting stents (DES). TBLs are characterized by the obstruction of both main vessel and side-branch. Limited data are available on long-term clinical outcome following TBL treatment with newer-generation DES. We performed an explorative sub-study of the randomized TWENTE trial among 287 patients who had bifurcated target lesions with side-branches ≥2.0 mm. Patients were categorized into TBL (Medina classes: 1.1.1; 1.0.1; 0.1.1) versus non-TBL to compare long-term clinical outcome. A total of 116 (40.4 %) patients had TBL, while 171 (59.6 %) had non-TBL only. Target-lesion revascularization rates were similar (3.5 vs. 3.5 %; p = 1.0), and definite-or-probable stent thrombosis rates were low (both <1.0 %). The target-vessel myocardial infarction (MI) rate was 11.3 versus 5.3 % (p = 0.06), mostly driven by (periprocedural) MI ≤48 h from PCI. All-cause mortality and cardiac death rates were 8.7 versus 3.5 % (p = 0.06) and 3.5 versus 1.2 % (p = 0.22), respectively. The 3-year major adverse cardiac event rate for patients with TBL versus non-TBL was 20.0 versus 11.7 % (p = 0.05). At 1-, 2-, and 3-year follow-up, 6.5, 13.0, and 11.0 % of patients reported chest pain at less than or equal moderate physical effort, respectively, without any between-group difference. Patients treated with second-generation DES for TBL had somewhat higher adverse event rates than patients with non-TBL, but dissimilarities did not reach statistical significance. Up to 3-year follow-up, the vast majority of patients of both groups remained free from chest pain.
dc.languageEnglish
dc.publisherSPRINGER
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleLong-term outcome and chest pain in patients with true versus non-true bifurcation lesions treated with second-generation drug-eluting stents in the TWENTE trial
dc.typeJournal Article
dc.identifier.doi10.1007/s00380-015-0786-6
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleHeart and Vessels: an international journal
melbourne.source.volume31
melbourne.source.issue11
melbourne.source.pages1731-1739
dc.rights.licenseCC BY
melbourne.elementsid1326342
melbourne.contributor.authorIJzerman, Maarten
dc.identifier.eissn1615-2573
melbourne.accessrightsOpen Access


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