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dc.contributor.authorKar, SP
dc.contributor.authorAndrulis, IL
dc.contributor.authorBrenner, H
dc.contributor.authorBurgess, S
dc.contributor.authorChang-Claude, J
dc.contributor.authorConsidine, D
dc.contributor.authorDoerk, T
dc.contributor.authorEvans, DGR
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGiles, GG
dc.contributor.authorHartman, M
dc.contributor.authorHuo, D
dc.contributor.authorKaaks, R
dc.contributor.authorLi, J
dc.contributor.authorLophatananon, A
dc.contributor.authorMargolin, S
dc.contributor.authorMilne, RL
dc.contributor.authorMuir, KR
dc.contributor.authorOlsson, H
dc.contributor.authorPunie, K
dc.contributor.authorRadice, P
dc.contributor.authorSimard, J
dc.contributor.authorTamimi, RM
dc.contributor.authorVan Nieuwenhuysen, E
dc.contributor.authorWendt, C
dc.contributor.authorZheng, W
dc.contributor.authorPharoah, PDP
dc.date.accessioned2020-12-10T01:43:22Z
dc.date.available2020-12-10T01:43:22Z
dc.date.issued2019-06-01
dc.identifierpii: 10.1007/s10654-019-00485-7
dc.identifier.citationKar, S. P., Andrulis, I. L., Brenner, H., Burgess, S., Chang-Claude, J., Considine, D., Doerk, T., Evans, D. G. R., Gago-Dominguez, M., Giles, G. G., Hartman, M., Huo, D., Kaaks, R., Li, J., Lophatananon, A., Margolin, S., Milne, R. L., Muir, K. R., Olsson, H. ,... Pharoah, P. D. P. (2019). The association between weight at birth and breast cancer risk revisited using Mendelian randomisation. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 34 (6), pp.591-600. https://doi.org/10.1007/s10654-019-00485-7.
dc.identifier.issn0393-2990
dc.identifier.urihttp://hdl.handle.net/11343/253775
dc.description.abstractObservational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10-8 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. BW predicted by the 41-SNP IV was not associated with overall breast cancer risk in inverse-variance weighted (IVW) univariable MR analysis of genetic association data from 122,977 breast cancer cases and 105,974 controls (odds ratio = 0.86 per 500 g higher BW; 95% confidence interval 0.73-1.01). Sensitivity analyses using four alternative methods and three alternative IVs, including an IV with 59 of the 60 BW-associated SNPs, yielded similar results. Multivariable MR adjusting for the effects of the 49-SNP IV on birth length, adult height, adult body mass index, age at menarche, and age at menopause using IVW and MR-Egger methods provided estimates consistent with univariable analyses. Results were also similar when all analyses were repeated after restricting to estrogen receptor-positive or -negative breast cancer cases. Point estimates of the odds ratios from most analyses performed indicated an inverse relationship between genetically-predicted BW and breast cancer, but we are unable to rule out an association between the non-genetically-determined component of BW and breast cancer. Thus, genetically-predicted higher BW was not associated with an increased risk of breast cancer in adult life in our MR study.
dc.languageEnglish
dc.publisherSPRINGER
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe association between weight at birth and breast cancer risk revisited using Mendelian randomisation
dc.typeJournal Article
dc.identifier.doi10.1007/s10654-019-00485-7
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleEuropean Journal of Epidemiology
melbourne.source.volume34
melbourne.source.issue6
melbourne.source.pages591-600
dc.rights.licenseCC BY
melbourne.elementsid1372360
melbourne.contributor.authorMilne, Roger
dc.identifier.eissn1573-7284
melbourne.accessrightsOpen Access


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