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dc.contributor.authorPulit, SL
dc.contributor.authorWeng, L-C
dc.contributor.authorMcArdle, PF
dc.contributor.authorTrinquart, L
dc.contributor.authorChoi, SH
dc.contributor.authorMitchell, BD
dc.contributor.authorRosand, J
dc.contributor.authorde Bakker, PIW
dc.contributor.authorBenjamin, EJ
dc.contributor.authorEllinor, PT
dc.contributor.authorKittner, SJ
dc.contributor.authorLubitz, SA
dc.contributor.authorAnderson, CD
dc.contributor.authorChristophersen, IE
dc.contributor.authorRienstra, M
dc.contributor.authorRoselli, C
dc.contributor.authorYin, X
dc.contributor.authorGeelhoed, B
dc.contributor.authorBarnard, J
dc.contributor.authorLin, H
dc.contributor.authorArking, DE
dc.contributor.authorSmith, A
dc.contributor.authorAlbert, CM
dc.contributor.authorChaffin, M
dc.contributor.authorTucker, NR
dc.contributor.authorLi, M
dc.contributor.authorKlarin, D
dc.contributor.authorBihlmeyer, NA
dc.contributor.authorLow, S-K
dc.contributor.authorWeeke, PE
dc.contributor.authorMueller-Nurasyid, M
dc.contributor.authorSmith, JG
dc.contributor.authorBrody, JA
dc.contributor.authorNiemeijer, MN
dc.contributor.authorDoerr, M
dc.contributor.authorTrompet, S
dc.contributor.authorHuffman, J
dc.contributor.authorGustafsson, S
dc.contributor.authorSchurmann, C
dc.contributor.authorKleber, ME
dc.contributor.authorLyytikainen, L-P
dc.contributor.authorSeppala, I
dc.contributor.authorMalik, R
dc.contributor.authorHorimoto, ARVR
dc.contributor.authorPerez, M
dc.contributor.authorSinisalo, J
dc.contributor.authorAeschbacher, S
dc.contributor.authorTheriault, S
dc.contributor.authorYao, J
dc.contributor.authorRadmanesh, F
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dc.contributor.authorTeumer, A
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dc.contributor.authorPerz, S
dc.contributor.authorPsaty, BM
dc.contributor.authorRidker, PM
dc.contributor.authorMagnani, JW
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dc.contributor.authorShoemaker, MB
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dc.contributor.authorKahonen, M
dc.contributor.authorRisch, L
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dc.contributor.authorBottinger, EB
dc.contributor.authorHernesniemi, J
dc.contributor.authorLindgren, CM
dc.contributor.authorWong, JA
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dc.contributor.authorReiner, AP
dc.contributor.authorDelgado, G
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dc.contributor.authorChen, Y-DI
dc.contributor.authorSandhu, RK
dc.contributor.authorLi, M
dc.contributor.authorBoerwinkle, E
dc.contributor.authorEisele, L
dc.contributor.authorLannfelt, L
dc.contributor.authorRost, N
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dc.contributor.authorCampbell, A
dc.contributor.authorMagnusson, PK
dc.contributor.authorPorteous, D
dc.contributor.authorHocking, LJ
dc.contributor.authorVlachopoulou, E
dc.contributor.authorPedersen, NL
dc.contributor.authorNikus, K
dc.contributor.authorOrho-Melander, M
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dc.contributor.authorHeeringa, J
dc.contributor.authorDenny, JC
dc.contributor.authorKriebel, J
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dc.contributor.authorNewton-Cheh, C
dc.contributor.authorShaffer, C
dc.contributor.authorMacfarlane, PW
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dc.contributor.authorAlmgren, P
dc.contributor.authorHuang, PL
dc.contributor.authorSotoodehnia, N
dc.contributor.authorSoliman, EZ
dc.contributor.authorUitterlinden, AG
dc.contributor.authorHofman, A
dc.contributor.authorFranco, OH
dc.contributor.authorVoelker, U
dc.contributor.authorJoeckel, K-H
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dc.contributor.authorLin, HJ
dc.contributor.authorGuo, X
dc.contributor.authorDichgans, M
dc.contributor.authorIngelsson, E
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dc.contributor.authorMelander, O
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dc.contributor.authorConen, D
dc.contributor.authorvan der Harst, P
dc.contributor.authorLokki, M-L
dc.contributor.authorKathiresan, S
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dc.contributor.authorJukema, JW
dc.contributor.authorHayward, C
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dc.contributor.authorChung, MK
dc.contributor.authorFelix, SB
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dc.contributor.authorPikula, A
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dc.contributor.authorde Bakker, P
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dc.contributor.authorHardy, J
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dc.contributor.authorWnuk, M
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dc.contributor.authorPera, J
dc.contributor.authorSlowik, A
dc.contributor.authorJuchniewicz, KJ
dc.contributor.authorLevi, C
dc.contributor.authorNyquist, P
dc.contributor.authorCendes, I
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dc.contributor.authorFranca, P
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dc.contributor.authorKeller, L
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dc.contributor.authorAhmadi, K
dc.contributor.authorOpherk, C
dc.contributor.authorDuering, M
dc.contributor.authorGonik, M
dc.contributor.authorStaals, J
dc.contributor.authorBurri, P
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dc.contributor.authorRomero, J
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dc.contributor.authorSchmidt, R
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dc.contributor.authorRundek, T
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dc.contributor.authorDeng, Z
dc.contributor.authorBarr, T
dc.contributor.authorGwinn, K
dc.contributor.authorCorriveau, R
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dc.contributor.authorLee, WL
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dc.contributor.authorChiou, HY
dc.contributor.authorChern, J
dc.contributor.authorGiraldo, E
dc.contributor.authorTaqi, M
dc.contributor.authorJain, V
dc.contributor.authorLam, O
dc.contributor.authorHoward, G
dc.contributor.authorWoo, D
dc.contributor.authorKittner, S
dc.contributor.authorMitchell, B
dc.contributor.authorCole, J
dc.contributor.authorO'Connell, J
dc.contributor.authorMilewicz, D
dc.contributor.authorIlloh, K
dc.contributor.authorWorrall, B
dc.contributor.authorStine, C
dc.contributor.authorKaraszewski, B
dc.contributor.authorWerring, D
dc.contributor.authorSofat, R
dc.contributor.authorSmalley, J
dc.contributor.authorLindgren, A
dc.contributor.authorHansen, B
dc.contributor.authorNorrving, B
dc.contributor.authorSmith, G
dc.contributor.authorJose Martin, J
dc.contributor.authorThijs, V
dc.contributor.authorKlijn, K
dc.contributor.authorvan't Hof, F
dc.contributor.authorAlgra, A
dc.contributor.authorMacleod, M
dc.contributor.authorPerry, R
dc.contributor.authorArnett, D
dc.contributor.authorPezzini, A
dc.contributor.authorPadovani, A
dc.contributor.authorCramer, S
dc.contributor.authorFisher, M
dc.contributor.authorSaleheen, D
dc.contributor.authorBroderick, J
dc.contributor.authorKissela, B
dc.contributor.authorDoney, A
dc.contributor.authorSudlow, C
dc.contributor.authorRannikmae, K
dc.contributor.authorSilliman, S
dc.contributor.authorMcDonough, C
dc.contributor.authorWalters, M
dc.contributor.authorPedersen, A
dc.contributor.authorNakagawa, K
dc.contributor.authorChang, C
dc.contributor.authorDobbins, M
dc.contributor.authorMcArdle, P
dc.contributor.authorChang, Y-C
dc.contributor.authorBrown, R
dc.contributor.authorBrown, D
dc.contributor.authorHolliday, E
dc.contributor.authorKalaria, R
dc.contributor.authorMaguire, J
dc.contributor.authorAttia, J
dc.contributor.authorFarrall, M
dc.contributor.authorGiese, A-K
dc.contributor.authorFornage, M
dc.contributor.authorMajersik, J
dc.contributor.authorCushman, M
dc.contributor.authorKeene, K
dc.contributor.authorBennett, S
dc.contributor.authorTirschwell, D
dc.contributor.authorPsaty, B
dc.contributor.authorReiner, A
dc.contributor.authorLongstreth, W
dc.contributor.authorSpence, D
dc.contributor.authorMontaner, J
dc.contributor.authorFernandez-Cadenas, I
dc.contributor.authorLangefeld, C
dc.contributor.authorBushnell, C
dc.contributor.authorHeitsch, L
dc.contributor.authorLee, J-M
dc.contributor.authorSheth, K
dc.date.accessioned2020-12-10T01:48:02Z
dc.date.available2020-12-10T01:48:02Z
dc.date.issued2018-12-01
dc.identifierpii: NG2018008771
dc.identifier.citationPulit, S. L., Weng, L. -C., McArdle, P. F., Trinquart, L., Choi, S. H., Mitchell, B. D., Rosand, J., de Bakker, P. I. W., Benjamin, E. J., Ellinor, P. T., Kittner, S. J., Lubitz, S. A., Anderson, C. D., Christophersen, I. E., Rienstra, M., Roselli, C., Yin, X., Geelhoed, B., Barnard, J. ,... Sheth, K. (2018). Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes. NEUROLOGY-GENETICS, 4 (6), https://doi.org/10.1212/NXG.0000000000000293.
dc.identifier.issn2376-7839
dc.identifier.urihttp://hdl.handle.net/11343/253799
dc.description.abstractObjective: We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. Methods: We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. Results: We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 × 10-4 in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 × 10-48), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07, p = 0.004), but no other primary stroke subtypes (all p > 0.1). Conclusions: Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
dc.languageEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleAtrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
dc.typeJournal Article
dc.identifier.doi10.1212/NXG.0000000000000293
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleNeurology Genetics
melbourne.source.volume4
melbourne.source.issue6
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1370975
melbourne.contributor.authorThijs, Vincent
dc.identifier.eissn2376-7839
melbourne.accessrightsOpen Access


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