University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Anatomy and Neuroscience
  • Anatomy and Neuroscience - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Anatomy and Neuroscience
  • Anatomy and Neuroscience - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Structurally defined signaling in neuro-glia units in the enteric nervous system

    Thumbnail
    Download
    Published version (4.893Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    4
    4
    Author
    Boesmans, W; Hao, MM; Fung, C; Li, Z; Van den Haute, C; Tack, J; Pachnis, V; Vanden Berghe, P
    Date
    2019-06-01
    Source Title
    Glia
    Publisher
    WILEY
    University of Melbourne Author/s
    Hao, Marlene
    Affiliation
    Anatomy and Neuroscience
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Boesmans, W., Hao, M. M., Fung, C., Li, Z., Van den Haute, C., Tack, J., Pachnis, V. & Vanden Berghe, P. (2019). Structurally defined signaling in neuro-glia units in the enteric nervous system. GLIA, 67 (6), pp.1167-1178. https://doi.org/10.1002/glia.23596.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253813
    DOI
    10.1002/glia.23596
    Abstract
    Coordination of gastrointestinal function relies on joint efforts of enteric neurons and glia, whose crosstalk is vital for the integration of their activity. To investigate the signaling mechanisms and to delineate the spatial aspects of enteric neuron-to-glia communication within enteric ganglia we developed a method to stimulate single enteric neurons while monitoring the activity of neighboring enteric glial cells. We combined cytosolic calcium uncaging of individual enteric neurons with calcium imaging of enteric glial cells expressing a genetically encoded calcium indicator and demonstrate that enteric neurons signal to enteric glial cells through pannexins using paracrine purinergic pathways. Sparse labeling of enteric neurons and high-resolution analysis of the structural relation between neuronal cell bodies, varicose release sites and enteric glia uncovered that this form of neuron-to-glia communication is contained between the cell body of an enteric neuron and its surrounding enteric glial cells. Our results reveal the spatial and functional foundation of neuro-glia units as an operational cellular assembly in the enteric nervous system.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Anatomy and Neuroscience - Research Publications [621]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors