Mitigation of Amyloidosis with Nanomaterials.

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Author
Ke, PC; Pilkington, EH; Sun, Y; Javed, I; Kakinen, A; Peng, G; Ding, F; Davis, TPDate
2020-05Source Title
Advanced MaterialsPublisher
WileyUniversity of Melbourne Author/s
Pilkington, EmilyAffiliation
Microbiology and ImmunologyMetadata
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Journal ArticleCitations
Ke, P. C., Pilkington, E. H., Sun, Y., Javed, I., Kakinen, A., Peng, G., Ding, F. & Davis, T. P. (2020). Mitigation of Amyloidosis with Nanomaterials.. Adv Mater, 32 (18), pp.e1901690-. https://doi.org/10.1002/adma.201901690.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904546Abstract
Amyloidosis is a biophysical phenomenon of protein aggregation with biological and pathogenic implications. Among the various strategies developed to date, nanomaterials and multifunctional nanocomposites possessing certain structural and physicochemical traits are promising candidates for mitigating amyloidosis in vitro and in vivo. The mechanisms underpinning protein aggregation and toxicity are introduced, and opportunities in materials science to drive this interdisciplinary field forward are highlighted. Advancement of this emerging frontier hinges on exploitation of protein self-assembly and interactions of amyloid proteins with nanoparticles, intracellular and extracellular proteins, chaperones, membranes, organelles, and biometals.
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