Mitigation of Amyloidosis with Nanomaterials.
AuthorKe, PC; Pilkington, EH; Sun, Y; Javed, I; Kakinen, A; Peng, G; Ding, F; Davis, TP
Source TitleAdvanced Materials
University of Melbourne Author/sPilkington, Emily
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsKe, P. C., Pilkington, E. H., Sun, Y., Javed, I., Kakinen, A., Peng, G., Ding, F. & Davis, T. P. (2020). Mitigation of Amyloidosis with Nanomaterials.. Adv Mater, 32 (18), pp.e1901690-. https://doi.org/10.1002/adma.201901690.
Access StatusOpen Access
Open Access URLAccepted version
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904546
Amyloidosis is a biophysical phenomenon of protein aggregation with biological and pathogenic implications. Among the various strategies developed to date, nanomaterials and multifunctional nanocomposites possessing certain structural and physicochemical traits are promising candidates for mitigating amyloidosis in vitro and in vivo. The mechanisms underpinning protein aggregation and toxicity are introduced, and opportunities in materials science to drive this interdisciplinary field forward are highlighted. Advancement of this emerging frontier hinges on exploitation of protein self-assembly and interactions of amyloid proteins with nanoparticles, intracellular and extracellular proteins, chaperones, membranes, organelles, and biometals.
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