Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

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    Author
    Patel, DM; Jones, RR; Booth, BJ; Olsson, AC; Kromhout, H; Straif, K; Vermeulen, R; Tikellis, G; Paltiel, O; Golding, J; ...
    Date
    2020-02-15
    Source Title
    International Journal of Cancer
    Publisher
    WILEY
    University of Melbourne Author/s
    Ponsonby, Anne-Louise; Dwyer, Terence
    Affiliation
    Melbourne School of Population and Global Health
    Paediatrics (RCH)
    Metadata
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    Document Type
    Journal Article
    Citations
    Patel, D. M., Jones, R. R., Booth, B. J., Olsson, A. C., Kromhout, H., Straif, K., Vermeulen, R., Tikellis, G., Paltiel, O., Golding, J., Northstone, K., Stoltenberg, C., Haberg, S. E., Schuz, J., Friesen, M. C., Ponsonby, A. -L., Lemeshow, S., Linet, M. S., Magnus, P. ,... Ward, M. H. (2020). Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). INTERNATIONAL JOURNAL OF CANCER, 146 (4), pp.943-952. https://doi.org/10.1002/ijc.32388.
    Access Status
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    URI
    http://hdl.handle.net/11343/253904
    DOI
    10.1002/ijc.32388
    Open Access URL
    Accepted version
    Abstract
    Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case-control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97-10.68; insecticides HR = 2.86, 95% CI = 0.99-8.23; animals HR = 3.89, 95% CI = 1.18-12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12-5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31-0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.

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