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dc.contributor.authorBarow, E
dc.contributor.authorBoutitie, F
dc.contributor.authorCheng, B
dc.contributor.authorCho, T-H
dc.contributor.authorEbinger, M
dc.contributor.authorEndres, M
dc.contributor.authorFiebach, JB
dc.contributor.authorFiehler, J
dc.contributor.authorFord, I
dc.contributor.authorGalinovic, I
dc.contributor.authorNickel, A
dc.contributor.authorPuig, J
dc.contributor.authorRoy, P
dc.contributor.authorWouters, A
dc.contributor.authorThijs, V
dc.contributor.authorLemmens, R
dc.contributor.authorMuir, KW
dc.contributor.authorNighoghossian, N
dc.contributor.authorPedraza, S
dc.contributor.authorSimonsen, CZ
dc.contributor.authorGerloff, C
dc.contributor.authorThomalla, G
dc.date.accessioned2020-12-14T05:19:23Z
dc.date.available2020-12-14T05:19:23Z
dc.date.issued2020-09-01
dc.identifierpii: 10.1007/s00062-019-00800-5
dc.identifier.citationBarow, E., Boutitie, F., Cheng, B., Cho, T. -H., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Ford, I., Galinovic, I., Nickel, A., Puig, J., Roy, P., Wouters, A., Thijs, V., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S. ,... Thomalla, G. (2020). Clinical Characteristics and Outcome of Patients with Lacunar Infarcts and Concurrent Embolic Ischemic Lesions. CLINICAL NEURORADIOLOGY, 30 (3), pp.511-516. https://doi.org/10.1007/s00062-019-00800-5.
dc.identifier.issn1869-1439
dc.identifier.urihttp://hdl.handle.net/11343/253906
dc.description.abstractPURPOSE: Lacunar infarcts are thought to result from occlusion of small penetrating arteries due to microatheroma and lipohyalinosis, pathognomonic for cerebral small vessel disease (CSVD). Concurrent embolic ischemic lesions indicate a different stroke mechanism. The purpose of this study was to examine the clinical characteristics and outcome of patients with lacunar infarcts and concurrent embolic infarcts on diffusion-weighted imaging (DWI). METHODS: All patients screened for the WAKE-UP trial (ClinicalTrials.gov number, NCT01525290) were reviewed for acute lacunar infarcts and concurrent embolic lesions on baseline DWI. Clinical characteristics and outcome were compared between lacunar infarct patients with and without concurrent embolic lesions. RESULTS: Of 244 patients with an acute lacunar infarct, 20 (8.2%) had concurrent acute embolic infarcts. Compared to patients with a lacunar infarct only, patients with concurrent embolic infarcts were older (mean age 69 years vs. 63 years; p = 0.031), more severely affected (median National Institutes of Health Stroke Scale [NIHSS] score 5 vs. 4; p = 0.046), and-among those randomized-had worse functional outcome at 90 days (median modified Rankin Scale [mRS] 3 vs. 1; p = 0.011). CONCLUSION: Approximately 8% of lacunar infarct patients show concurrent embolic lesions suggesting a stroke etiology other than CSVD. These patients are more severely affected and have a worse functional outcome illustrating the need for a thorough diagnostic work-up of possible embolic sources even in patients with an imaging-defined diagnosis of lacunar infarcts.
dc.languageEnglish
dc.publisherSPRINGER HEIDELBERG
dc.titleClinical Characteristics and Outcome of Patients with Lacunar Infarcts and Concurrent Embolic Ischemic Lesions
dc.typeJournal Article
dc.identifier.doi10.1007/s00062-019-00800-5
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleClinical Neuroradiology
melbourne.source.volume30
melbourne.source.issue3
melbourne.source.pages511-516
melbourne.elementsid1397348
melbourne.openaccess.urlhttp://eprints.gla.ac.uk/186596/7/186596.pdf
melbourne.openaccess.statusAccepted version
melbourne.contributor.authorThijs, Vincent
dc.identifier.eissn1869-1447
melbourne.accessrightsAccess this item via the Open Access location


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