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    Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

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    Author
    Kong, X-Z; Boedhoe, PSW; Abe, Y; Alonso, P; Ameis, SH; Arnold, PD; Assogna, F; Baker, JT; Batistuzzo, MC; Benedetti, F; ...
    Date
    2020-06-15
    Source Title
    Biological Psychiatry
    Publisher
    ELSEVIER SCIENCE INC
    University of Melbourne Author/s
    Schmaal, Lianne
    Affiliation
    Centre for Youth Mental Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Kong, X. -Z., Boedhoe, P. S. W., Abe, Y., Alonso, P., Ameis, S. H., Arnold, P. D., Assogna, F., Baker, J. T., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Brennan, B. P., Buitelaar, J., Calvo, R., Cheng, Y., Cho, K. I. K. ,... Francks, C. (2020). Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. BIOLOGICAL PSYCHIATRY, 87 (12), pp.1022-1034. https://doi.org/10.1016/j.biopsych.2019.04.022.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/253909
    DOI
    10.1016/j.biopsych.2019.04.022
    Open Access URL
    http://europepmc.org/articles/pmc7094802?pdf=render
    Abstract
    BACKGROUND: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. METHODS: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. RESULTS: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. CONCLUSIONS: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

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