Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance.
AuthorStern, Y; Arenaza-Urquijo, EM; Bartrés-Faz, D; Belleville, S; Cantilon, M; Chetelat, G; Ewers, M; Franzmeier, N; Kempermann, G; Kremen, WS; ...
Source TitleAlzheimer's and Dementia
University of Melbourne Author/sLim, Yen Ying
AffiliationFlorey Department of Neuroscience and Mental Health
Document TypeJournal Article
CitationsStern, Y., Arenaza-Urquijo, E. M., Bartrés-Faz, D., Belleville, S., Cantilon, M., Chetelat, G., Ewers, M., Franzmeier, N., Kempermann, G., Kremen, W. S., Okonkwo, O., Scarmeas, N., Soldan, A., Udeh-Momoh, C., Valenzuela, M., Vemuri, P., Vuoksimaa, E. & the Reserve, Resilience and Protective Factors PIA Empirical Definitions and Conceptual Frameworks Workgroup, (2020). Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance.. Alzheimers Dement, 16 (9), pp.1305-1311. https://doi.org/10.1016/j.jalz.2018.07.219.
Access StatusAccess this item via the Open Access location
Open Access URLAccepted version
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417987
Several concepts, which in the aggregate get might be used to account for "resilience" against age- and disease-related changes, have been the subject of much research. These include brain reserve, cognitive reserve, and brain maintenance. However, different investigators have use these terms in different ways, and there has never been an attempt to arrive at consensus on the definition of these concepts. Furthermore, there has been confusion regarding the measurement of these constructs and the appropriate ways to apply them to research. Therefore the reserve, resilience, and protective factors professional interest area, established under the auspices of the Alzheimer's Association, established a whitepaper workgroup to develop consensus definitions for cognitive reserve, brain reserve, and brain maintenance. The workgroup also evaluated measures that have been used to implement these concepts in research settings and developed guidelines for research that explores or utilizes these concepts. The workgroup hopes that this whitepaper will form a reference point for researchers in this area and facilitate research by supplying a common language.
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