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dc.contributor.authorColich, NL
dc.contributor.authorPlatt, JM
dc.contributor.authorKeyes, KM
dc.contributor.authorSumner, JA
dc.contributor.authorAllen, NB
dc.contributor.authorMcLaughlin, KA
dc.date.accessioned2020-12-14T05:26:29Z
dc.date.available2020-12-14T05:26:29Z
dc.date.issued2020-05
dc.identifierpii: S0033291719000953
dc.identifier.citationColich, N. L., Platt, J. M., Keyes, K. M., Sumner, J. A., Allen, N. B. & McLaughlin, K. A. (2020). Earlier age at menarche as a transdiagnostic mechanism linking childhood trauma with multiple forms of psychopathology in adolescent girls.. Psychol Med, 50 (7), pp.1090-1098. https://doi.org/10.1017/S0033291719000953.
dc.identifier.issn0033-2917
dc.identifier.urihttp://hdl.handle.net/11343/253919
dc.description.abstractBACKGROUND: Although early life adversity (ELA) increases risk for psychopathology, mechanisms linking ELA with the onset of psychopathology remain poorly understood. Conceptual models have argued that ELA accelerates development. It is unknown whether all forms of ELA are associated with accelerated development or whether early maturation is a potential mechanism linking ELA with psychopathology. We examine whether two distinct dimensions of ELA - threat and deprivation - have differential associations with pubertal timing in girls, and evaluate whether accelerated pubertal timing is a mechanism linking ELA with the onset of adolescent psychopathology. METHODS: Data were drawn from a large, nationally representative sample of 4937 adolescent girls. Multiple forms of ELA characterized by threat and deprivation were assessed along with age at menarche (AAM) and the onset of DSM-IV fear, distress, externalizing, and eating disorders. RESULTS: Greater exposure to threat was associated with earlier AAM (B = -0.1, p = 0.001). Each 1-year increase in AAM was associated with reduced odds of fear, distress, and externalizing disorders post-menarche (ORs = 0.74-0.85). Earlier AAM significantly mediated the association between exposure to threat and post-menarche onset of distress (proportion mediated = 6.2%), fear (proportion mediated = 16.3%), and externalizing disorders (proportion mediated = 2.9%). CONCLUSIONS: Accelerated pubertal development in girls may be one transdiagnostic pathway through which threat-related experiences confer risk for the adolescent onset of mental disorders. Early pubertal maturation is a marker that could be used in both medical and mental health settings to identify trauma-exposed youth that are at risk for developing a mental disorder during adolescence in order to better target early interventions.
dc.languageeng
dc.publisherCambridge University Press (CUP)
dc.titleEarlier age at menarche as a transdiagnostic mechanism linking childhood trauma with multiple forms of psychopathology in adolescent girls.
dc.typeJournal Article
dc.identifier.doi10.1017/S0033291719000953
melbourne.affiliation.departmentMelbourne School of Psychological Sciences
melbourne.source.titlePsychological Medicine
melbourne.source.volume50
melbourne.source.issue7
melbourne.source.pages1090-1098
melbourne.elementsid1392758
melbourne.openaccess.urlhttp://europepmc.org/articles/pmc6814488?pdf=render
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814488
melbourne.openaccess.statusAccepted version
melbourne.contributor.authorAllen, Nicholas
dc.identifier.eissn1469-8978
melbourne.accessrightsAccess this item via the Open Access location


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