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dc.contributor.authorCampbell, PT
dc.contributor.authorTong, SYC
dc.contributor.authorGeard, N
dc.contributor.authorDavies, MR
dc.contributor.authorWorthing, KA
dc.contributor.authorLacey, JA
dc.contributor.authorSmeesters, PR
dc.contributor.authorBatzloff, MR
dc.contributor.authorKado, J
dc.contributor.authorJenney, AWJ
dc.contributor.authorMcvernon, J
dc.contributor.authorSteer, AC
dc.identifierpii: 5636896
dc.identifier.citationCampbell, P. T., Tong, S. Y. C., Geard, N., Davies, M. R., Worthing, K. A., Lacey, J. A., Smeesters, P. R., Batzloff, M. R., Kado, J., Jenney, A. W. J., Mcvernon, J. & Steer, A. C. (2020). Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.. Journal of Infectious Diseases, 221 (9), pp.1429-1437.
dc.description.abstractGroup A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relationship between infection, colonization, and immunity is still not completely understood. The M protein, encoded by the emm gene, is a major virulence factor and vaccine candidate and forms the basis of a number of classification systems. Longitudinal patterns of emm types collected from 457 Fijian schoolchildren over a 10-month period were analyzed. No evidence of tissue tropism was observed, and there was no apparent selective pressure or constraint of emm types. Patterns of emm type acquisition suggest limited, if any, modification of future infection based on infection history. Where impetigo is the dominant mode of transmission, circulating emm types either may not be constrained by ecological niches or population immunity to the M protein, or they may require several infections over a longer period of time to induce such immunity.
dc.publisherOxford University Press (OUP)
dc.titleLongitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.
dc.typeJournal Article
melbourne.affiliation.departmentDoherty Institute
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentComputing and Information Systems
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleJournal of Infectious Diseases
melbourne.openaccess.statusPublished version
melbourne.contributor.authorSmeesters, Pierre
melbourne.contributor.authorMcVernon, Jodie
melbourne.contributor.authorJenney, Adam
melbourne.contributor.authorGeard, Nicholas
melbourne.contributor.authorSteer, Andrew
melbourne.contributor.authorCampbell, Patricia
melbourne.contributor.authorDavies, Mark
melbourne.contributor.authorTong, Steven
melbourne.contributor.authorLacey, Jake
melbourne.contributor.authorWorthing, Kate
melbourne.identifier.fundernameidNHMRC, 1098319
melbourne.identifier.fundernameidNHMRC, 1145033
melbourne.identifier.fundernameidNHMRC, 1117140
melbourne.identifier.fundernameidNHMRC, 1130455
melbourne.accessrightsAccess this item via the Open Access location

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