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    Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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    Author
    Coleman, JRI; Peyrot, WJ; Purves, KL; Davis, KAS; Rayner, C; Choi, SW; Hubel, C; Gaspar, HA; Kan, C; Van der Auwera, S; ...
    Date
    2020-01-23
    Source Title
    Molecular Psychiatry
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Baune, Bernhard
    Affiliation
    Psychiatry
    Metadata
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    Document Type
    Journal Article
    Citations
    Coleman, J. R. I., Peyrot, W. J., Purves, K. L., Davis, K. A. S., Rayner, C., Choi, S. W., Hubel, C., Gaspar, H. A., Kan, C., Van der Auwera, S., Adams, M. J., Lyall, D. M., Choi, K. W., Dunn, E. C., Vassos, E., Danese, A., Maughan, B., Grabe, H. J., Lewis, C. M. ,... Sullivan, P. F. (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. MOLECULAR PSYCHIATRY, 25 (7), pp.1430-1446. https://doi.org/10.1038/s41380-019-0546-6.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254009
    DOI
    10.1038/s41380-019-0546-6
    Open Access URL
    http://europepmc.org/articles/pmc7305950?pdf=render
    Abstract
    Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8 × 10-7 versus rg = -0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10-4). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.

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