Effectiveness of the Genomics ADvISER decision aid for the selection of secondary findings from genomic sequencing: a randomized clinical trial
Author
Bombard, Y; Clausen, M; Shickh, S; Mighton, C; Casalino, S; Kim, THM; Muir, SM; Carlsson, L; Baxter, N; Scheer, A; ...Date
2020-04-01Source Title
Genetics in MedicinePublisher
NATURE PUBLISHING GROUPUniversity of Melbourne Author/s
Baxter, NancyAffiliation
Melbourne School of Population and Global HealthMetadata
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Journal ArticleCitations
Bombard, Y., Clausen, M., Shickh, S., Mighton, C., Casalino, S., Kim, T. H. M., Muir, S. M., Carlsson, L., Baxter, N., Scheer, A., Elser, C., Eisen, A., Panchal, S., Graham, T., Aronson, M., Piccinin, C., Mancuso, T., Semotiuk, K., Evans, M. ,... Laupacis, A. (2020). Effectiveness of the Genomics ADvISER decision aid for the selection of secondary findings from genomic sequencing: a randomized clinical trial. GENETICS IN MEDICINE, 22 (4), pp.727-735. https://doi.org/10.1038/s41436-019-0702-z.Access Status
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425118Abstract
PURPOSE: To evaluate the effectiveness of the Genomics ADvISER (www.genomicsadviser.com) decision aid (DA) for selection of secondary findings (SF), compared with genetic counseling alone. METHODS: A randomized controlled trial (RCT) was conducted to evaluate whether the Genomics ADvISER is superior to genetic counseling when hypothetically selecting SF. Participants were randomized to use the DA followed by discussion with a genetic counselor, or to genetic counseling alone. Surveys were administered at baseline and post-intervention. Primary outcome was decisional conflict. Secondary outcomes were knowledge, preparation for, and satisfaction with decision-making, anxiety, and length of counseling session. RESULTS: Participants (n = 133) were predominantly White/European (74%), female (90%), and ≥50 years old (60%). Decisional conflict (mean difference 0.05; P = 0.60), preparation for decision-making (0.17; P = 0.95), satisfaction with decision (-2.18; P = 0.06), anxiety (0.72; P = 0.56), and knowledge of sequencing limitations (0.14; P = 0.70) did not significantly differ between groups. However, intervention participants had significantly higher knowledge of SF (0.39; P < 0.001) and sequencing benefits (0.97; P = 0.01), and significantly shorter counseling time (24.40 minutes less; P < 0.001) CONCLUSIONS: The Genomics ADvISER did not decrease decisional conflict but reduced counseling time and improved knowledge. This decision aid could serve as an educational tool, reducing in-clinic time and potentially health care costs.
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