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dc.contributor.authorBombard, Y
dc.contributor.authorClausen, M
dc.contributor.authorShickh, S
dc.contributor.authorMighton, C
dc.contributor.authorCasalino, S
dc.contributor.authorKim, THM
dc.contributor.authorMuir, SM
dc.contributor.authorCarlsson, L
dc.contributor.authorBaxter, N
dc.contributor.authorScheer, A
dc.contributor.authorElser, C
dc.contributor.authorEisen, A
dc.contributor.authorPanchal, S
dc.contributor.authorGraham, T
dc.contributor.authorAronson, M
dc.contributor.authorPiccinin, C
dc.contributor.authorMancuso, T
dc.contributor.authorSemotiuk, K
dc.contributor.authorEvans, M
dc.contributor.authorCarroll, JC
dc.contributor.authorOffit, K
dc.contributor.authorRobson, M
dc.contributor.authorHamilton, JG
dc.contributor.authorGlogowski, E
dc.contributor.authorSchrader, K
dc.contributor.authorKim, RH
dc.contributor.authorLerner-Ellis, J
dc.contributor.authorThorpe, KE
dc.contributor.authorLaupacis, A
dc.date.accessioned2020-12-14T05:49:00Z
dc.date.available2020-12-14T05:49:00Z
dc.date.issued2020-04-01
dc.identifierpii: 10.1038/s41436-019-0702-z
dc.identifier.citationBombard, Y., Clausen, M., Shickh, S., Mighton, C., Casalino, S., Kim, T. H. M., Muir, S. M., Carlsson, L., Baxter, N., Scheer, A., Elser, C., Eisen, A., Panchal, S., Graham, T., Aronson, M., Piccinin, C., Mancuso, T., Semotiuk, K., Evans, M. ,... Laupacis, A. (2020). Effectiveness of the Genomics ADvISER decision aid for the selection of secondary findings from genomic sequencing: a randomized clinical trial. GENETICS IN MEDICINE, 22 (4), pp.727-735. https://doi.org/10.1038/s41436-019-0702-z.
dc.identifier.issn1098-3600
dc.identifier.urihttp://hdl.handle.net/11343/254010
dc.description.abstractPURPOSE: To evaluate the effectiveness of the Genomics ADvISER (www.genomicsadviser.com) decision aid (DA) for selection of secondary findings (SF), compared with genetic counseling alone. METHODS: A randomized controlled trial (RCT) was conducted to evaluate whether the Genomics ADvISER is superior to genetic counseling when hypothetically selecting SF. Participants were randomized to use the DA followed by discussion with a genetic counselor, or to genetic counseling alone. Surveys were administered at baseline and post-intervention. Primary outcome was decisional conflict. Secondary outcomes were knowledge, preparation for, and satisfaction with decision-making, anxiety, and length of counseling session. RESULTS: Participants (n = 133) were predominantly White/European (74%), female (90%), and ≥50 years old (60%). Decisional conflict (mean difference 0.05; P = 0.60), preparation for decision-making (0.17; P = 0.95), satisfaction with decision (-2.18; P = 0.06), anxiety (0.72; P = 0.56), and knowledge of sequencing limitations (0.14; P = 0.70) did not significantly differ between groups. However, intervention participants had significantly higher knowledge of SF (0.39; P < 0.001) and sequencing benefits (0.97; P = 0.01), and significantly shorter counseling time (24.40 minutes less; P < 0.001) CONCLUSIONS: The Genomics ADvISER did not decrease decisional conflict but reduced counseling time and improved knowledge. This decision aid could serve as an educational tool, reducing in-clinic time and potentially health care costs.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleEffectiveness of the Genomics ADvISER decision aid for the selection of secondary findings from genomic sequencing: a randomized clinical trial
dc.typeJournal Article
dc.identifier.doi10.1038/s41436-019-0702-z
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleGenetics in Medicine
melbourne.source.volume22
melbourne.source.issue4
melbourne.source.pages727-735
melbourne.elementsid1433314
melbourne.openaccess.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425118
melbourne.openaccess.statusAccepted version
melbourne.contributor.authorBaxter, Nancy
dc.identifier.eissn1530-0366
melbourne.accessrightsAccess this item via the Open Access location


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