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dc.contributor.authorFonseca, R
dc.contributor.authorBeura, LK
dc.contributor.authorQuarnstrom, CF
dc.contributor.authorGhoneim, HE
dc.contributor.authorFan, Y
dc.contributor.authorZebley, CC
dc.contributor.authorScott, MC
dc.contributor.authorFares-Frederickson, NJ
dc.contributor.authorWijeyesinghe, S
dc.contributor.authorThompson, EA
dc.contributor.authorBorges da Silva, H
dc.contributor.authorVezys, V
dc.contributor.authorYoungblood, B
dc.contributor.authorMasopust, D
dc.identifierpii: 10.1038/s41590-020-0607-7
dc.identifier.citationFonseca, R., Beura, L. K., Quarnstrom, C. F., Ghoneim, H. E., Fan, Y., Zebley, C. C., Scott, M. C., Fares-Frederickson, N. J., Wijeyesinghe, S., Thompson, E. A., Borges da Silva, H., Vezys, V., Youngblood, B. & Masopust, D. (2020). Developmental plasticity allows outside-in immune responses by resident memory T cells. NATURE IMMUNOLOGY, 21 (4), pp.412-+.
dc.description.abstractCentral memory T (TCM) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (TRM) cells are parked within single organs, share properties with terminal effectors and contribute to rapid host protection. We observed that reactivated TRM cells rejoined the circulating pool. Epigenetic analyses revealed that TRM cells align closely with conventional memory T cell populations, bearing little resemblance to recently activated effectors. Fully differentiated TRM cells isolated from small intestine epithelium exhibited the potential to differentiate into TCM cells, effector memory T cells and TRM cells on recall. Ex-TRM cells, former intestinal TRM cells that rejoined the circulating pool, heritably maintained a predilection for homing back to their tissue of origin on subsequent reactivation and a heightened capacity to redifferentiate into TRM cells. Thus, TRM cells can rejoin the circulation but are advantaged to re-form local TRM when called on.
dc.titleDevelopmental plasticity allows outside-in immune responses by resident memory T cells
dc.typeJournal Article
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleNature Immunology
melbourne.openaccess.statusAccepted version
melbourne.contributor.authorFonseca, Raissa
melbourne.accessrightsAccess this item via the Open Access location

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