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dc.contributor.authorVasanthakumar, A
dc.contributor.authorChisanga, D
dc.contributor.authorBlume, J
dc.contributor.authorGloury, R
dc.contributor.authorBritt, K
dc.contributor.authorHenstridge, DC
dc.contributor.authorZhan, Y
dc.contributor.authorTorres, SV
dc.contributor.authorLiene, S
dc.contributor.authorCollins, N
dc.contributor.authorCao, E
dc.contributor.authorSidwell, T
dc.contributor.authorLi, C
dc.contributor.authorSpallanzani, RG
dc.contributor.authorLiao, Y
dc.contributor.authorBeavis, PA
dc.contributor.authorGebhardt, T
dc.contributor.authorTrevaskis, N
dc.contributor.authorNutt, SL
dc.contributor.authorZajac, JD
dc.contributor.authorDavey, RA
dc.contributor.authorFebbraio, MA
dc.contributor.authorMathis, D
dc.contributor.authorShi, W
dc.contributor.authorKallies, A
dc.date.accessioned2020-12-14T05:54:36Z
dc.date.available2020-12-14T05:54:36Z
dc.date.issued2020-02-26
dc.identifierpii: 10.1038/s41586-020-2040-3
dc.identifier.citationVasanthakumar, A., Chisanga, D., Blume, J., Gloury, R., Britt, K., Henstridge, D. C., Zhan, Y., Torres, S. V., Liene, S., Collins, N., Cao, E., Sidwell, T., Li, C., Spallanzani, R. G., Liao, Y., Beavis, P. A., Gebhardt, T., Trevaskis, N., Nutt, S. L. ,... Kallies, A. (2020). Sex-specific adipose tissue imprinting of regulatory T cells. NATURE, 579 (7800), pp.581-+. https://doi.org/10.1038/s41586-020-2040-3.
dc.identifier.issn0028-0836
dc.identifier.urihttp://hdl.handle.net/11343/254043
dc.description.abstractAdipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for the regulation of systemic metabolism3,4. Impaired VAT function-for example, in obesity-is associated with insulin resistance and type 2 diabetes5,6. Regulatory T (Treg) cells that express the transcription factor FOXP3 are critical for limiting immune responses and suppressing tissue inflammation, including in the VAT7-9. Here we uncover pronounced sexual dimorphism in Treg cells in the VAT. Male VAT was enriched for Treg cells compared with female VAT, and Treg cells from male VAT were markedly different from their female counterparts in phenotype, transcriptional landscape and chromatin accessibility. Heightened inflammation in the male VAT facilitated the recruitment of Treg cells via the CCL2-CCR2 axis. Androgen regulated the differentiation of a unique IL-33-producing stromal cell population specific to the male VAT, which paralleled the local expansion of Treg cells. Sex hormones also regulated VAT inflammation, which shaped the transcriptional landscape of VAT-resident Treg cells in a BLIMP1 transcription factor-dependent manner. Overall, we find that sex-specific differences in Treg cells from VAT are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
dc.languageEnglish
dc.publisherNATURE RESEARCH
dc.titleSex-specific adipose tissue imprinting of regulatory T cells
dc.typeJournal Article
dc.identifier.doi10.1038/s41586-020-2040-3
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleNature
melbourne.source.volume579
melbourne.source.issue7800
melbourne.source.pages581-+
melbourne.elementsid1438758
melbourne.openaccess.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241647
melbourne.openaccess.statusAccepted version
melbourne.contributor.authorBlume, Jonas
melbourne.contributor.authorKallies, Axel
melbourne.contributor.authorDavey, Rachel
melbourne.contributor.authorZajac, Jeffrey
melbourne.contributor.authorGebhardt, Thomas
melbourne.contributor.authorBeavis, Paul
melbourne.contributor.authorVasanthakumar, Ajithkumar
melbourne.contributor.authorShi, Wei
melbourne.contributor.authorChisanga, David
melbourne.contributor.authorGloury, Renee
melbourne.contributor.authorBritt, Kara
melbourne.contributor.authorZhan, Yifan
melbourne.contributor.authorValle Torres, Stalin Santiago
melbourne.contributor.authorLiene, Sebastian
melbourne.contributor.authorCOLLINS, NICHOLAS
melbourne.contributor.authorSidwell, Tom
melbourne.contributor.authorLiao, Yang
melbourne.contributor.authorNutt, Stephen
dc.identifier.eissn1476-4687
melbourne.accessrightsAccess this item via the Open Access location


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