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dc.contributor.authorGrasby, KL
dc.contributor.authorJahanshad, N
dc.contributor.authorPainter, JN
dc.contributor.authorColodro-Conde, L
dc.contributor.authorBralten, J
dc.contributor.authorHibar, DP
dc.contributor.authorLind, PA
dc.contributor.authorPizzagalli, F
dc.contributor.authorChing, CRK
dc.contributor.authorMcMahon, MAB
dc.contributor.authorShatokhina, N
dc.contributor.authorZsembik, LCP
dc.contributor.authorThomopoulos, SI
dc.contributor.authorZhu, AH
dc.contributor.authorStrike, LT
dc.contributor.authorAgartz, I
dc.contributor.authorAlhusaini, S
dc.contributor.authorAlmeida, MAA
dc.contributor.authorAlnaes, D
dc.contributor.authorAmlien, IK
dc.contributor.authorAndersson, M
dc.contributor.authorArd, T
dc.contributor.authorArmstrong, NJ
dc.contributor.authorAshley-Koch, A
dc.contributor.authorAtkins, JR
dc.contributor.authorBernard, M
dc.contributor.authorBrouwer, RM
dc.contributor.authorBuimer, EEL
dc.contributor.authorBulow, R
dc.contributor.authorBurger, C
dc.contributor.authorCannon, DM
dc.contributor.authorChakravarty, M
dc.contributor.authorChen, Q
dc.contributor.authorCheung, JW
dc.contributor.authorCouvy-Duchesne, B
dc.contributor.authorDale, AM
dc.contributor.authorDalvie, S
dc.contributor.authorde Araujo, TK
dc.contributor.authorde Zubicaray, GI
dc.contributor.authorde Zwarte, SMC
dc.contributor.authorden Braber, A
dc.contributor.authorNhat, TD
dc.contributor.authorDohm, K
dc.contributor.authorEhrlich, S
dc.contributor.authorEngelbrecht, H-R
dc.contributor.authorErk, S
dc.contributor.authorFan, CC
dc.contributor.authorFedko, IO
dc.contributor.authorFoley, SF
dc.contributor.authorFord, JM
dc.contributor.authorFukunaga, M
dc.contributor.authorGarrett, ME
dc.contributor.authorGe, T
dc.contributor.authorGiddaluru, S
dc.contributor.authorGoldman, AL
dc.contributor.authorGreen, MJ
dc.contributor.authorGroenewold, NA
dc.contributor.authorGrotegerd, D
dc.contributor.authorGurholt, TP
dc.contributor.authorGutman, BA
dc.contributor.authorHansell, NK
dc.contributor.authorHarris, MA
dc.contributor.authorHarrison, MB
dc.contributor.authorHaswell, CC
dc.contributor.authorHauser, M
dc.contributor.authorHerms, S
dc.contributor.authorHeslenfeld, DJ
dc.contributor.authorHo, NF
dc.contributor.authorHoehn, D
dc.contributor.authorHoffmann, P
dc.contributor.authorHolleran, L
dc.contributor.authorHoogman, M
dc.contributor.authorHottenga, J-J
dc.contributor.authorIkeda, M
dc.contributor.authorJanowitz, D
dc.contributor.authorJansen, IE
dc.contributor.authorJia, T
dc.contributor.authorJockwitz, C
dc.contributor.authorKanai, R
dc.contributor.authorKarama, S
dc.contributor.authorKasperaviciute, D
dc.contributor.authorKaufmann, T
dc.contributor.authorKelly, S
dc.contributor.authorKikuchi, M
dc.contributor.authorKlein, M
dc.contributor.authorKnapp, M
dc.contributor.authorKnodt, AR
dc.contributor.authorKramer, B
dc.contributor.authorLam, M
dc.contributor.authorLancaster, TM
dc.contributor.authorLee, PH
dc.contributor.authorLett, TA
dc.contributor.authorLewis, LB
dc.contributor.authorLopes-Cendes, I
dc.contributor.authorLuciano, M
dc.contributor.authorMacciardi, F
dc.contributor.authorMarquand, AF
dc.contributor.authorMathias, SR
dc.contributor.authorMelzer, TR
dc.contributor.authorMilaneschi, Y
dc.contributor.authorMirza-Schreiber, N
dc.contributor.authorMoreira, JCV
dc.contributor.authorMuhleisen, TW
dc.contributor.authorMueller-Myhsok, B
dc.contributor.authorNajt, P
dc.contributor.authorNakahara, S
dc.contributor.authorNho, K
dc.contributor.authorLoohuis, LMO
dc.contributor.authorOrfanos, DP
dc.contributor.authorPearson, JF
dc.contributor.authorPitcher, TL
dc.contributor.authorPutz, B
dc.contributor.authorQuide, Y
dc.contributor.authorRagothaman, A
dc.contributor.authorRashid, FM
dc.contributor.authorReay, WR
dc.contributor.authorRedlich, R
dc.contributor.authorReinbold, CS
dc.contributor.authorRepple, J
dc.contributor.authorRichard, G
dc.contributor.authorRiedel, BC
dc.contributor.authorRisacher, SL
dc.contributor.authorRocha, CS
dc.contributor.authorMota, NR
dc.contributor.authorSalminen, L
dc.contributor.authorSaremi, A
dc.contributor.authorSaykin, AJ
dc.contributor.authorSchlag, F
dc.contributor.authorSchmaal, L
dc.contributor.authorSchofield, PR
dc.contributor.authorSecolin, R
dc.contributor.authorShapland, CY
dc.contributor.authorShen, L
dc.contributor.authorShin, J
dc.contributor.authorShumskaya, E
dc.contributor.authorSonderby, IE
dc.contributor.authorSprooten, E
dc.contributor.authorTansey, KE
dc.contributor.authorTeumer, A
dc.contributor.authorThalamuthu, A
dc.contributor.authorTordesillas-Gutierrez, D
dc.contributor.authorTurner, JA
dc.contributor.authorUhlmann, A
dc.contributor.authorVallerga, CL
dc.contributor.authorvan der Meer, D
dc.contributor.authorvan Donkelaar, MMJ
dc.contributor.authorvan Eijk, L
dc.contributor.authorvan Erp, TGM
dc.contributor.authorvan Haren, NEM
dc.contributor.authorvan Rooij, D
dc.contributor.authorvan Tol, M-J
dc.contributor.authorVeldink, JH
dc.contributor.authorVerhoef, E
dc.contributor.authorWalton, E
dc.contributor.authorWang, M
dc.contributor.authorWang, Y
dc.contributor.authorWardlaw, JM
dc.contributor.authorWen, W
dc.contributor.authorWestlye, LT
dc.contributor.authorWhelan, CD
dc.contributor.authorWitt, SH
dc.contributor.authorWittfeld, K
dc.contributor.authorWolf, C
dc.contributor.authorWolfers, T
dc.contributor.authorWu, JQ
dc.contributor.authorYasuda, CL
dc.contributor.authorZaremba, D
dc.contributor.authorZhang, Z
dc.contributor.authorZwiers, MP
dc.contributor.authorArtiges, E
dc.contributor.authorAssareh, AA
dc.contributor.authorAyesa-Arriola, R
dc.contributor.authorBelger, A
dc.contributor.authorBrandt, CL
dc.contributor.authorBrown, GG
dc.contributor.authorCichon, S
dc.contributor.authorCurran, JE
dc.contributor.authorDavies, GE
dc.contributor.authorDegenhardt, F
dc.contributor.authorDennis, MF
dc.contributor.authorDietsche, B
dc.contributor.authorDjurovic, S
dc.contributor.authorDoherty, CP
dc.contributor.authorEspiritu, R
dc.contributor.authorGarijo, D
dc.contributor.authorGil, Y
dc.contributor.authorGowland, PA
dc.contributor.authorGreen, RC
dc.contributor.authorHausler, AN
dc.contributor.authorHeindel, W
dc.contributor.authorHo, B-C
dc.contributor.authorHoffmann, WU
dc.contributor.authorHolsboer, F
dc.contributor.authorHomuth, G
dc.contributor.authorHosten, N
dc.contributor.authorJack, CR
dc.contributor.authorJang, M
dc.contributor.authorJansen, A
dc.contributor.authorKimbrel, NA
dc.contributor.authorKolskar, K
dc.contributor.authorKoops, S
dc.contributor.authorKrug, A
dc.contributor.authorLim, KO
dc.contributor.authorLuykx, JJ
dc.contributor.authorMathalon, DH
dc.contributor.authorMather, KA
dc.contributor.authorMattay, VS
dc.contributor.authorMatthews, S
dc.contributor.authorVan Son, JM
dc.contributor.authorMcEwen, SC
dc.contributor.authorMelle, I
dc.contributor.authorMorris, DW
dc.contributor.authorMueller, BA
dc.contributor.authorNauck, M
dc.contributor.authorNordvik, JE
dc.contributor.authorNoethen, MM
dc.contributor.authorO'Leary, DS
dc.contributor.authorOpel, N
dc.contributor.authorMartinot, M-LP
dc.contributor.authorPike, GB
dc.contributor.authorPreda, A
dc.contributor.authorQuinlan, EB
dc.contributor.authorRasser, PE
dc.contributor.authorRatnakar, V
dc.contributor.authorReppermund, S
dc.contributor.authorSteen, VM
dc.contributor.authorTooney, PA
dc.contributor.authorTorres, FR
dc.contributor.authorVeltman, DJ
dc.contributor.authorVoyvodic, JT
dc.contributor.authorWhelan, R
dc.contributor.authorWhite, T
dc.contributor.authorYamamori, H
dc.contributor.authorAdams, HHH
dc.contributor.authorBis, JC
dc.contributor.authorDebette, S
dc.contributor.authorDecarli, C
dc.contributor.authorFornage, M
dc.contributor.authorGudnason, V
dc.contributor.authorHofer, E
dc.contributor.authorIkram, MA
dc.contributor.authorLauner, L
dc.contributor.authorLongstreth, WT
dc.contributor.authorLopez, OL
dc.contributor.authorMazoyer, B
dc.contributor.authorMosley, TH
dc.contributor.authorRoshchupkin, GV
dc.contributor.authorSatizabal, CL
dc.contributor.authorSchmidt, R
dc.contributor.authorSeshadri, S
dc.contributor.authorYang, Q
dc.contributor.authorAlvim, MKM
dc.contributor.authorAmes, D
dc.contributor.authorAnderson, TJ
dc.contributor.authorAndreassen, OA
dc.contributor.authorArias-Vasquez, A
dc.contributor.authorBastin, ME
dc.contributor.authorBaune, BT
dc.contributor.authorBeckham, JC
dc.contributor.authorBlangero, J
dc.contributor.authorBoomsma, DI
dc.contributor.authorBrodaty, H
dc.contributor.authorBrunner, HG
dc.contributor.authorBuckner, RL
dc.contributor.authorBuitelaar, JK
dc.contributor.authorBustillo, JR
dc.contributor.authorCahn, W
dc.contributor.authorCairns, MJ
dc.contributor.authorCalhoun, V
dc.contributor.authorCarr, VJ
dc.contributor.authorCaseras, X
dc.contributor.authorCaspers, S
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dc.contributor.authorCendes, F
dc.contributor.authorCorvin, A
dc.contributor.authorCrespo-Facorro, B
dc.contributor.authorDalrymple-Alford, JC
dc.contributor.authorDannlowski, U
dc.contributor.authorde Geus, EJC
dc.contributor.authorDeary, IJ
dc.contributor.authorDelanty, N
dc.contributor.authorDepondt, C
dc.contributor.authorDesrivieres, S
dc.contributor.authorDonohoe, G
dc.contributor.authorEspeseth, T
dc.contributor.authorFernandez, G
dc.contributor.authorFisher, SE
dc.contributor.authorFlor, H
dc.contributor.authorForstner, AJ
dc.contributor.authorFrancks, C
dc.contributor.authorFranke, B
dc.contributor.authorGlahn, DC
dc.contributor.authorGollub, RL
dc.contributor.authorGrabe, HJ
dc.contributor.authorGruber, O
dc.contributor.authorHaberg, AK
dc.contributor.authorHariri, AR
dc.contributor.authorHartman, CA
dc.contributor.authorHashimoto, R
dc.contributor.authorHeinz, A
dc.contributor.authorHenskens, FA
dc.contributor.authorHillegers, MHJ
dc.contributor.authorHoekstra, PJ
dc.contributor.authorHolmes, AJ
dc.contributor.authorHong, LE
dc.contributor.authorHopkins, WD
dc.contributor.authorPol, HEH
dc.contributor.authorJernigan, TL
dc.contributor.authorJonsson, EG
dc.contributor.authorKahn, RS
dc.contributor.authorKennedy, MA
dc.contributor.authorKircher, TTJ
dc.contributor.authorKochunov, P
dc.contributor.authorKwok, JBJ
dc.contributor.authorLe Hellard, S
dc.contributor.authorLoughland, CM
dc.contributor.authorMartin, NG
dc.contributor.authorMartinot, J-L
dc.contributor.authorMcDonald, C
dc.contributor.authorMcMahon, KL
dc.contributor.authorMeyer-Lindenberg, A
dc.contributor.authorMichie, PT
dc.contributor.authorMorey, RA
dc.contributor.authorMowry, B
dc.contributor.authorNyberg, L
dc.contributor.authorOosterlaan, J
dc.contributor.authorOphoff, RA
dc.contributor.authorPantelis, C
dc.contributor.authorPaus, T
dc.contributor.authorPausova, Z
dc.contributor.authorPenninx, BWJH
dc.contributor.authorPolderman, TJC
dc.contributor.authorPosthuma, D
dc.contributor.authorRietschel, M
dc.contributor.authorRoffman, JL
dc.contributor.authorRowland, LM
dc.contributor.authorSachdev, PS
dc.contributor.authorSamann, PG
dc.contributor.authorSchall, U
dc.contributor.authorSchumann, G
dc.contributor.authorScott, RJ
dc.contributor.authorSim, K
dc.contributor.authorSisodiya, SM
dc.contributor.authorSmoller, JW
dc.contributor.authorSommer, IE
dc.contributor.authorSt Pourcain, B
dc.contributor.authorStein, DJ
dc.contributor.authorToga, AW
dc.contributor.authorTrollor, JN
dc.contributor.authorVan der Wee, NJA
dc.contributor.authorvan't Ent, D
dc.contributor.authorVolzke, H
dc.contributor.authorWalter, H
dc.contributor.authorWeber, B
dc.contributor.authorWeinberger, DR
dc.contributor.authorWright, MJ
dc.contributor.authorZhou, J
dc.contributor.authorStein, JL
dc.contributor.authorThompson, PM
dc.contributor.authorMedland, SE
dc.date.accessioned2020-12-14T05:55:39Z
dc.date.available2020-12-14T05:55:39Z
dc.date.issued2020-03-20
dc.identifierpii: 367/6484/eaay6690
dc.identifier.citationGrasby, K. L., Jahanshad, N., Painter, J. N., Colodro-Conde, L., Bralten, J., Hibar, D. P., Lind, P. A., Pizzagalli, F., Ching, C. R. K., McMahon, M. A. B., Shatokhina, N., Zsembik, L. C. P., Thomopoulos, S. I., Zhu, A. H., Strike, L. T., Agartz, I., Alhusaini, S., Almeida, M. A. A., Alnaes, D. ,... Medland, S. E. (2020). The genetic architecture of the human cerebral cortex. SCIENCE, 367 (6484), pp.1340-+. https://doi.org/10.1126/science.aay6690.
dc.identifier.issn0036-8075
dc.identifier.urihttp://hdl.handle.net/11343/254050
dc.description.abstractThe cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
dc.languageEnglish
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE
dc.titleThe genetic architecture of the human cerebral cortex
dc.typeJournal Article
dc.identifier.doi10.1126/science.aay6690
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.source.titleScience
melbourne.source.volume367
melbourne.source.issue6484
melbourne.source.pages1340-+
melbourne.identifier.nhmrc628386
melbourne.identifier.nhmrc1105825
melbourne.elementsid1443176
melbourne.openaccess.urlhttp://orca.cf.ac.uk/130555/1/130555.pdf
melbourne.openaccess.statusAccepted version
melbourne.contributor.authorPantelis, Christos
melbourne.contributor.authorSchmaal, Lianne
melbourne.contributor.authorBaune, Bernhard
melbourne.contributor.authorAmes, David
dc.identifier.eissn1095-9203
melbourne.identifier.fundernameidNHMRC, 628386
melbourne.identifier.fundernameidNHMRC, 1105825
melbourne.identifier.fundernameidNATIONAL INSTITUTE OF HEALTH, R01MH117601 / 108606875
melbourne.accessrightsAccess this item via the Open Access location


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