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    Characteristics and treatment regimens across ERS SHARP severe asthma registries

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    Author
    van Bragt, JJMH; Adcock, IM; Bel, EHD; Braunstahl, G-J; ten Brinke, A; Busby, J; Canonica, GW; Cao, H; Chung, KF; Csoma, Z; ...
    Date
    2020-01-01
    Source Title
    European Respiratory Journal
    Publisher
    EUROPEAN RESPIRATORY SOC JOURNALS LTD
    University of Melbourne Author/s
    Anderson, Gary
    Affiliation
    Pharmacology and Therapeutics
    Metadata
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    Document Type
    Journal Article
    Citations
    van Bragt, J. J. M. H., Adcock, I. M., Bel, E. H. D., Braunstahl, G. -J., ten Brinke, A., Busby, J., Canonica, G. W., Cao, H., Chung, K. F., Csoma, Z., Dahlen, B., Davin, E., Hansen, S., Heffler, E., Horvath, I., Korn, S., Kots, M., Kuna, P., Kwon, N. ,... Zimmermann, R. (2020). Characteristics and treatment regimens across ERS SHARP severe asthma registries. EUROPEAN RESPIRATORY JOURNAL, 55 (1), https://doi.org/10.1183/13993003.01163-2019.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254053
    DOI
    10.1183/13993003.01163-2019
    Open Access URL
    https://air.unimi.it/bitstream/2434/759932/2/1901163.full.pdf
    Abstract
    Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m-2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day-1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day-1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.

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