University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Medicine and Radiology
  • Medicine and Radiology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Medicine and Radiology
  • Medicine and Radiology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    6
    5
    Author
    Marshall, PR; Zhao, Q; Li, X; Wei, W; Periyakaruppiah, A; Zajaczkowski, EL; Leighton, LJ; Madugalle, SU; Basic, D; Wang, Z; ...
    Date
    2020-05-04
    Source Title
    Nature Neuroscience
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Walkley, Carl
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Marshall, P. R., Zhao, Q., Li, X., Wei, W., Periyakaruppiah, A., Zajaczkowski, E. L., Leighton, L. J., Madugalle, S. U., Basic, D., Wang, Z., Yin, J., Liau, W. -S., Gupte, A., Walkley, C. R. & Bredy, T. W. (2020). Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction. NATURE NEUROSCIENCE, 23 (6), pp.718-+. https://doi.org/10.1038/s41593-020-0627-5.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254063
    DOI
    10.1038/s41593-020-0627-5
    Open Access URL
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269834
    Abstract
    DNA forms conformational states beyond the right-handed double helix; however, the functional relevance of these noncanonical structures in the brain remains unknown. Here we show that, in the prefrontal cortex of mice, the formation of one such structure, Z-DNA, is involved in the regulation of extinction memory. Z-DNA is formed during fear learning and reduced during extinction learning, which is mediated, in part, by a direct interaction between Z-DNA and the RNA-editing enzyme Adar1. Adar1 binds to Z-DNA during fear extinction learning, which leads to a reduction in Z-DNA at sites where Adar1 is recruited. Knockdown of Adar1 leads to an inability to modify a previously acquired fear memory and blocks activity-dependent changes in DNA structure and RNA state-effects that are fully rescued by the introduction of full-length Adar1. These findings suggest a new mechanism of learning-induced gene regulation that is dependent on proteins that recognize alternate DNA structure states, which are required for memory flexibility.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53102]
    • Medicine and Radiology - Research Publications [3320]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors