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    Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes

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    Author
    Shin, J; Ma, S; Hofer, E; Patel, Y; Vosberg, DE; Tilley, S; Roshchupkin, G; Sousa, AMM; Jian, X; Gottesman, R; ...
    Date
    2020-07-01
    Source Title
    Cerebral Cortex
    Publisher
    OXFORD UNIV PRESS INC
    University of Melbourne Author/s
    Ames, David
    Affiliation
    Psychiatry
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Shin, J., Ma, S., Hofer, E., Patel, Y., Vosberg, D. E., Tilley, S., Roshchupkin, G., Sousa, A. M. M., Jian, X., Gottesman, R., Mosley, T. H., Fornage, M., Saba, Y., Pirpamer, L., Schmidt, R., Schmidt, H., Carrion-Castillo, A., Crivello, F., Mazoyer, B. ,... Paus, T. (2020). Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes. CEREBRAL CORTEX, 30 (7), pp.4121-4139. https://doi.org/10.1093/cercor/bhaa035.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254065
    DOI
    10.1093/cercor/bhaa035
    Open Access URL
    https://pure.mpg.de/pubman/item/item_3215799_2/component/file_3215848/bhaa035_20-03-2020.pdf
    Abstract
    We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.

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