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dc.contributor.authorGc, VS
dc.contributor.authorFranklin, D
dc.contributor.authorWhitty, JA
dc.contributor.authorDalziel, SR
dc.contributor.authorBabl, FE
dc.contributor.authorSchlapbach, LJ
dc.contributor.authorFraser, JF
dc.contributor.authorCraig, S
dc.contributor.authorNeutze, J
dc.contributor.authorOakley, E
dc.contributor.authorSchibler, A
dc.date.accessioned2020-12-14T05:58:42Z
dc.date.available2020-12-14T05:58:42Z
dc.date.issued2020-10-01
dc.identifierpii: archdischild-2019-318427
dc.identifier.citationGc, V. S., Franklin, D., Whitty, J. A., Dalziel, S. R., Babl, F. E., Schlapbach, L. J., Fraser, J. F., Craig, S., Neutze, J., Oakley, E. & Schibler, A. (2020). First-line oxygen therapy with high-flow in bronchiolitis is not cost saving for the health service. ARCHIVES OF DISEASE IN CHILDHOOD, 105 (10), pp.975-980. https://doi.org/10.1136/archdischild-2019-318427.
dc.identifier.issn0003-9888
dc.identifier.urihttp://hdl.handle.net/11343/254068
dc.description.abstractBACKGROUND: Bronchiolitis is the most common reason for hospital admission in infants. High-flow oxygen therapy has emerged as a new treatment; however, the cost-effectiveness of using it as first-line therapy is unknown. OBJECTIVE: To compare the cost of providing high-flow therapy as a first-line therapy compared with rescue therapy after failure of standard oxygen in the management of bronchiolitis. METHODS: A within-trial economic evaluation from the health service perspective using data from a multicentre randomised controlled trial for hypoxic infants (≤12 months) admitted to hospital with bronchiolitis in Australia and New Zealand. Intervention costs, length of hospital and intensive care stay and associated costs were compared for infants who received first-line treatment with high-flow therapy (early high-flow, n=739) or for infants who received standard oxygen and optional rescue high-flow (rescue high-flow, n=733). Costs were applied using Australian costing sources and are reported in 2016-2017 AU$. RESULTS: The incremental cost to avoid one treatment failure was AU$1778 (95% credible interval (CrI) 207 to 7096). Mean cost of bronchiolitis treatment including intervention costs and costs associated with length of stay was AU$420 (95% CrI -176 to 1002) higher per infant in the early high-flow group compared with the rescue high-flow group. There was an 8% (95% CrI 7.5 to 8.6) likelihood of the early high-flow oxygen therapy being cost saving. CONCLUSIONS: The use of high-flow oxygen as initial therapy for respiratory failure in infants with bronchiolitis is unlikely to be cost saving to the health system, compared with standard oxygen therapy with rescue high-flow.
dc.languageEnglish
dc.publisherBMJ PUBLISHING GROUP
dc.titleFirst-line oxygen therapy with high-flow in bronchiolitis is not cost saving for the health service
dc.typeJournal Article
dc.identifier.doi10.1136/archdischild-2019-318427
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.department
melbourne.source.titleArchives of Disease in Childhood
melbourne.source.volume105
melbourne.source.issue10
melbourne.source.pages975-980
melbourne.elementsid1445576
melbourne.openaccess.urlhttp://eprints.whiterose.ac.uk/159689/1/Gc_et_al_Archdischild_Manuscript_CleanCopy_for_pure.docx
melbourne.openaccess.statusAccepted version
melbourne.contributor.authorBabl, Franz
melbourne.contributor.authorOakley, Edward
melbourne.contributor.authorOakley, Edward
dc.identifier.eissn1468-2044
melbourne.accessrightsAccess this item via the Open Access location


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