University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis

    Thumbnail
    Citations
    Altmetric
    Author
    Simpson-Yap, S; Oddy, WH; Taylor, B; Lucas, RM; Black, LJ; Ponsonby, A-L; Blizzard, L; van der Mei, I
    Date
    2020-07-23
    Source Title
    Multiple Sclerosis Journal
    Publisher
    SAGE PUBLICATIONS LTD
    University of Melbourne Author/s
    Simpson-Yap, Steve; Kilpatrick, Trevor
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Simpson-Yap, S., Oddy, W. H., Taylor, B., Lucas, R. M., Black, L. J., Ponsonby, A. -L., Blizzard, L. & van der Mei, I. (2020). High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL, https://doi.org/10.1177/1352458520943087.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254113
    DOI
    10.1177/1352458520943087
    Open Access URL
    https://eprints.utas.edu.au/34633/2/140317%20-%20High%20Prudent%20diet%20factor%20score%20predicts%20-%20Final%20author%20version.pdf
    Abstract
    BACKGROUND: Dietary patterns and their association with subsequent clinical course have not been well studied in early multiple sclerosis (MS). OBJECTIVES: To describe dietary patterns in people in 5 years following first clinical demyelination and assess associations with MS conversion and relapse. METHODS: This study included baseline food frequency questionnaire dietary intake (entry to the Ausimmune Study) and 5-year follow-up; iterated principal factor analysis was applied. MS conversion and relapse risks were assessed by Cox proportional hazards models, adjusted for age, sex, study site, education, body mass index (BMI), smoking and omega-3 supplement use. RESULTS: In cases with a first clinical diagnosis of central nervous system (CNS) demyelination, we identified three major dietary patterns, 'Prudent', 'High-Vegetable' and 'Mixed', explaining 43%, 37% and 24% of diet variance in dietary intake, respectively. Fruits, vegetables, fish, wholegrains and nuts loaded highly on the Prudent pattern, starchy vegetables and legumes on the High-Vegetable pattern, and meats and alcohol on the Mixed pattern. Diet factor scores were not associated with MS conversion risk. Those with baseline Prudent scores above the median had significantly lower relapse risk (adjusted hazard ratio = 0.54, 95% confidence interval (CI) 0.37, 0.81) with some evidence of a plateau effect. CONCLUSION: Prudent diet factor score above the median was prospectively associated with lower relapse risk in the 5 years following the first clinical demyelinating event.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Melbourne School of Population and Global Health - Research Publications [4369]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1052]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors