High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis
AuthorSimpson-Yap, S; Oddy, WH; Taylor, B; Lucas, RM; Black, LJ; Ponsonby, A-L; Blizzard, L; van der Mei, I
Source TitleMultiple Sclerosis Journal
PublisherSAGE PUBLICATIONS LTD
University of Melbourne Author/sSimpson-Yap, Steve; Kilpatrick, Trevor; Ponsonby, Anne-Louise; Dwyer, Terence
AffiliationFlorey Department of Neuroscience and Mental Health
Melbourne School of Population and Global Health
Document TypeJournal Article
CitationsSimpson-Yap, S., Oddy, W. H., Taylor, B., Lucas, R. M., Black, L. J., Ponsonby, A. -L., Blizzard, L. & van der Mei, I. (2020). High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL, 27 (7), pp.1112-1124. https://doi.org/10.1177/1352458520943087.
Access StatusAccess this item via the Open Access location
Open Access URLAccepted version
BACKGROUND: Dietary patterns and their association with subsequent clinical course have not been well studied in early multiple sclerosis (MS). OBJECTIVES: To describe dietary patterns in people in 5 years following first clinical demyelination and assess associations with MS conversion and relapse. METHODS: This study included baseline food frequency questionnaire dietary intake (entry to the Ausimmune Study) and 5-year follow-up; iterated principal factor analysis was applied. MS conversion and relapse risks were assessed by Cox proportional hazards models, adjusted for age, sex, study site, education, body mass index (BMI), smoking and omega-3 supplement use. RESULTS: In cases with a first clinical diagnosis of central nervous system (CNS) demyelination, we identified three major dietary patterns, 'Prudent', 'High-Vegetable' and 'Mixed', explaining 43%, 37% and 24% of diet variance in dietary intake, respectively. Fruits, vegetables, fish, wholegrains and nuts loaded highly on the Prudent pattern, starchy vegetables and legumes on the High-Vegetable pattern, and meats and alcohol on the Mixed pattern. Diet factor scores were not associated with MS conversion risk. Those with baseline Prudent scores above the median had significantly lower relapse risk (adjusted hazard ratio = 0.54, 95% confidence interval (CI) 0.37, 0.81) with some evidence of a plateau effect. CONCLUSION: Prudent diet factor score above the median was prospectively associated with lower relapse risk in the 5 years following the first clinical demyelinating event.
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