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dc.contributor.authorStehmann, C
dc.contributor.authorSenesi, M
dc.contributor.authorSarros, S
dc.contributor.authorMcGlade, A
dc.contributor.authorSimpson, M
dc.contributor.authorKlug, G
dc.contributor.authorMcLean, C
dc.contributor.authorMasters, CL
dc.contributor.authorCollins, S
dc.identifier.citationStehmann, C., Senesi, M., Sarros, S., McGlade, A., Simpson, M., Klug, G., McLean, C., Masters, C. L. & Collins, S. (2020). Creutzfeldt-Jakob disease surveillance in Australia: update to 31 December. COMMUNICABLE DISEASES INTELLIGENCE, 44 (2),
dc.description.abstractNationwide surveillance of Creutzfeldt-Jakob disease and other human prion diseases is performed by the Australian National Creutzfeldt-Jakob Disease Registry (ANCJDR). National surveillance encompasses the period since 1 January 1970, with prospective surveillance occurring from 1 October 1993. Over this prospective surveillance period, considerable developments have occurred in pre-mortem diagnostics; in the delineation of new disease subtypes; and in a heightened awareness of prion diseases in healthcare settings. Surveillance practices of the ANCJDR have evolved and adapted accordingly. This report summarises the activities of the ANCJDR during 2019. Since the ANCJDR began offering diagnostic cerebrospinal fluid (CSF) 14-3-3 protein testing in Australia in September 1997, the annual number of referrals has steadily increased. In 2019, 513 domestic CSF specimens were referred for 14-3-3 protein testing and 85 persons with suspected human prion disease were formally added to the national register. As of 31 December 2019, just under half (42 cases) of the 85 suspect case notifications remain classified as 'incomplete'; 16 cases were excluded through either detailed clinical follow-up (3 cases) or neuropathological examination (13 cases); 20 cases were classified as 'definite' and seven as 'probable' prion disease. For 2019, sixty-three percent of all suspected human prion disease related deaths in Australia underwent neuropathological examination. No cases of variant or iatrogenic CJD were identified. Two possibly causal novel prion protein gene (PRNP) sequence variations were identified.
dc.titleCreutzfeldt-Jakob disease surveillance in Australia: update to 31 December
dc.typeJournal Article
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleCommunicable Diseases Intelligence Quarterly Report
melbourne.openaccess.statusPublished version
melbourne.contributor.authorStehmann, Christiane
melbourne.contributor.authorMasters, Colin
melbourne.contributor.authorCollins, Steven
melbourne.contributor.authorSarros, Shannon
melbourne.contributor.authorMcLean, Catriona
melbourne.contributor.authorSenesi, Matteo
melbourne.contributor.authorBOYD, ALISON
melbourne.accessrightsAccess this item via the Open Access location

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