1,3-Dichloroacetone: A Robust Reagent for Preparing Bicyclic Peptides
AuthorLin, Q; Hopper, D; Zhang, H; Qoon, JS; Shen, Z; Karas, JA; Hughes, RA; Northfield, SE
Source TitleACS Omega
PublisherAMER CHEMICAL SOC
AffiliationSchool of Chemistry
Pharmacology and Therapeutics
Document TypeJournal Article
CitationsLin, Q., Hopper, D., Zhang, H., Qoon, J. S., Shen, Z., Karas, J. A., Hughes, R. A. & Northfield, S. E. (2020). 1,3-Dichloroacetone: A Robust Reagent for Preparing Bicyclic Peptides. ACS OMEGA, 5 (4), pp.1840-1850. https://doi.org/10.1021/acsomega.9b03152.
Access StatusAccess this item via the Open Access location
Open Access URLhttp://doi.org/10.1021/acsomega.9b03152
The chemical synthesis of cyclic peptides is a well-established area of research. This has been further expanded by development of bio-orthogonal reactions that enable access to peptides of greater structural complexity. One approach utilizes 1,3-dichloroacetone to selectively link free cysteine side-chains with an acetone-like bridge via an SN2 reaction. Here, we have used this reaction to dimerize cyclic peptide monomers to create novel bicyclic dimeric peptides. We investigated a range of reaction parameters to identify the optimal dimerization conditions for our model systems. One of the acetone-linked dimeric peptides was analyzed for proteolytic stability in human serum and was observed to still be fully intact after 48 h. This study provides valuable insights into the application of 1,3-dichloroacetone as a tool in the synthesis of complex, multicyclic peptides.
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