Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China
Author
Zhou, K; Xiao, T; David, S; Wang, Q; Zhou, Y; Guo, L; Aanensen, D; Holt, KE; Thomson, NR; Grundmann, H; ...Date
2020-02-01Source Title
Emerging Infectious DiseasesPublisher
CENTERS DISEASE CONTROL & PREVENTIONUniversity of Melbourne Author/s
Holt, KathrynAffiliation
Biochemistry and Molecular BiologyMetadata
Show full item recordDocument Type
Journal ArticleCitations
Zhou, K., Xiao, T., David, S., Wang, Q., Zhou, Y., Guo, L., Aanensen, D., Holt, K. E., Thomson, N. R., Grundmann, H., Shen, P. & Xiao, Y. (2020). Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China. EMERGING INFECTIOUS DISEASES, 26 (2), pp.289-297. https://doi.org/10.3201/eid2602.190594.Access Status
Access this item via the Open Access locationOpen Access URL
http://doi.org/10.3201/eid2602.190594Abstract
We aimed to clarify the epidemiologic and clinical importance of evolutionary events that occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). We collected 203 CRKP causing bloodstream infections in a tertiary hospital in China during 2013-2017. We detected a subclonal shift in the dominant clone sequence type (ST) 11 CRKP in which the previously prevalent capsular loci (KL) 47 had been replaced by KL64 since 2016. Patients infected with ST11-KL64 CRKP had a significantly higher 30-day mortality rate than other CRKP-infected patients. Enhanced virulence was further evidenced by phenotypic tests. Phylogenetic reconstruction demonstrated that ST11-KL64 is derived from an ST11-KL47-like ancestor through recombination. We identified a pLVPK-like virulence plasmid carrying rmpA and peg-344 in ST11-KL64 exclusively from 2016 onward. The pLVPK-like-positive ST11-KL64 isolates exhibited enhanced environmental survival. Retrospective screening of a national collection identified ST11-KL64 in multiple regions. Targeted surveillance of this high-risk CRKP clone is urgently needed.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References