Show simple item record

dc.contributor.authorMaziarz, RT
dc.contributor.authorWaller, EK
dc.contributor.authorJaeger, U
dc.contributor.authorFleury, I
dc.contributor.authorMcGuirk, J
dc.contributor.authorHolte, H
dc.contributor.authorJaglowski, S
dc.contributor.authorSchuster, SJ
dc.contributor.authorBishop, MR
dc.contributor.authorWestin, JR
dc.contributor.authorMielke, S
dc.contributor.authorTeshima, T
dc.contributor.authorBachanova, V
dc.contributor.authorFoley, SR
dc.contributor.authorBorchmann, P
dc.contributor.authorSalles, GA
dc.contributor.authorZhang, J
dc.contributor.authorTiwari, R
dc.contributor.authorPacaud, LB
dc.contributor.authorMa, Q
dc.contributor.authorTam, CS
dc.date.accessioned2020-12-14T06:17:34Z
dc.date.available2020-12-14T06:17:34Z
dc.date.issued2020-02-25
dc.identifierpii: S2473-9529(20)31468-3
dc.identifier.citationMaziarz, R. T., Waller, E. K., Jaeger, U., Fleury, I., McGuirk, J., Holte, H., Jaglowski, S., Schuster, S. J., Bishop, M. R., Westin, J. R., Mielke, S., Teshima, T., Bachanova, V., Foley, S. R., Borchmann, P., Salles, G. A., Zhang, J., Tiwari, R., Pacaud, L. B. ,... Tam, C. S. (2020). Patient-reported long-term quality of life after tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma. BLOOD ADVANCES, 4 (4), pp.629-637. https://doi.org/10.1182/bloodadvances.2019001026.
dc.identifier.issn2473-9529
dc.identifier.urihttp://hdl.handle.net/11343/254173
dc.description.abstractThe JULIET phase 2 trial evaluated a single infusion of tisagenlecleucel in adult patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL). The objective of the current analysis was to evaluate patient-reported health-related quality of life (HRQoL) with a median follow-up of 19.3 months among patients infused with a single dose of tisagenlecleucel. Patients enrolled were ≥18 years of age with r/r DLBCL after ≥2 lines of therapy and had either undergone a failed autologous stem cell transplant or were ineligible for the procedure. Two validated HRQoL instruments, Functional Assessment of Cancer Therapy-Lymphoma (FACT-Lym) and Short Form-36 (SF-36) Health Survey, were used to measure HRQoL at baseline and months 3, 6, 12, and 18. At data cutoff (21 May 2018), 115 patients had received tisagenlecleucel infusion. Among the 99 patients evaluated, overall response rate was 54%, and 40% of patients achieved complete response (CR). Initially, 108 patients completed the HRQoL assessments at baseline, including 57 patients who eventually achieved CR or partial response (PR). Further, 30 and 21 patients in clinical response who completed assessments at baseline also completed assessments at months 12 and 18, respectively. Patients who achieved CR or PR sustained HRQoL improvement in all FACT scores at all time points. SF-36 instruments showed improvement above the minimal clinically important differences on 5 of 8 subscales. Long-term follow-up in the phase 2 JULIET study demonstrated that patients with r/r DLBCL who respond to tisagenlecleucel therapy had sustained, clinically meaningful improvements in HRQoL. This trial was registered at www.clinicaltrials.gov as #NCT02445248.
dc.languageEnglish
dc.publisherAMER SOC HEMATOLOGY
dc.titlePatient-reported long-term quality of life after tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma
dc.typeJournal Article
dc.identifier.doi10.1182/bloodadvances.2019001026
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleBlood Advances
melbourne.source.volume4
melbourne.source.issue4
melbourne.source.pages629-637
melbourne.elementsid1441923
melbourne.openaccess.urlhttp://doi.org/10.1182/bloodadvances.2019001026
melbourne.openaccess.statusPublished version
melbourne.contributor.authorTam, Constantine
dc.identifier.eissn2473-9537
melbourne.accessrightsAccess this item via the Open Access location


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record