University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    A head-to-head comparison of cerebral blood flow SPECT and 18 F-FDG PET in the diagnosis of Alzheimer's Disease.

    Thumbnail
    Citations
    Altmetric
    Author
    Nadebaum, DP; Krishnadas, N; Poon, AM; Kalff, V; Lichtenstein, M; Villemagne, VL; Jones, G; Rowe, CC
    Date
    2020-05-10
    Source Title
    Internal Medicine Journal
    Publisher
    Wiley
    University of Melbourne Author/s
    Villemagne, Victor; Rowe, Christopher; Nadebaum, David; Krishnadas, Natasha; Krishnadas, Natasha; Poon, Aurora; KALFF, VICTOR; Lichtenstein, Meir
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Medicine and Radiology
    Medical Education
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Nadebaum, D. P., Krishnadas, N., Poon, A. M., Kalff, V., Lichtenstein, M., Villemagne, V. L., Jones, G. & Rowe, C. C. (2020). A head-to-head comparison of cerebral blood flow SPECT and 18 F-FDG PET in the diagnosis of Alzheimer's Disease.. Intern Med J, https://doi.org/10.1111/imj.14890.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254209
    DOI
    10.1111/imj.14890
    Open Access URL
    http://doi.org/10.1111/imj.14890
    Abstract
    BACKGROUND: Clinical diagnosis of Alzheimer's disease (AD) is only 70% accurate. Reduced cerebral blood flow (CBF) and metabolism in parieto-temporal and posterior cingulate cortex may assist diagnosis. Whilst widely accepted that 18 F-FDG PET has superior accuracy to CBF SPECT for AD, there is very limited head-to-head data from clinically relevant populations and these studies relied on clinical diagnosis as the reference standard. AIM: To directly compare the accuracy of CBF-SPECT and 18 F-FDG PET in patients referred for diagnostic studies in detecting β-amyloid PET confirmed AD. METHODS: 126 patients, 56% with mild cognitive impairment and 44% with dementia, completed both CBF-SPECT and 18 F-FDG PET as part of their diagnostic assessment, and subsequently underwent β-amyloid PET for research purposes. Transaxial slices and Neurostat 3D-SSP analyses of 18 F-FDG PET and CBF-SPECT scans were independently reviewed by five nuclear medicine clinicians blinded to all other data. Operators selected the most likely diagnosis and their diagnostic confidence. Accuracy analysis used final diagnosis incorporating β-amyloid PET as the reference standard. RESULTS: Clinicians reported high diagnostic confidence in 83% of 18 F-FDG PET compared to 67% for CBF-SPECT (p=0.001). All reviewers showed individually higher accuracy using 18 F-FDG PET. Based on majority read, the combined AUROC in diagnosing AD was 0.71 for 18 F-FDG PET and 0.61 for CBF-SPECT (p=0.02). The sensitivity of 18 F-FDG PET and CBF-SPECT was 76% vs 43% (p<0.001), whilst specificity was 74% vs 83% (p=0.45). CONCLUSION: 18 F-FDG PET is superior to CBF-SPECT in detecting Alzheimer's disease amongst patients referred for the assessment of cognitive impairment. This article is protected by copyright. All rights reserved.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53102]
    • Medical Education - Research Publications [599]
    • Medicine and Radiology - Research Publications [3320]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1300]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors