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dc.contributor.authorWorthing, KA
dc.contributor.authorWerno, A
dc.contributor.authorPink, R
dc.contributor.authorMcIntyre, L
dc.contributor.authorCarter, GP
dc.contributor.authorWilliamson, DA
dc.contributor.authorDavies, MR
dc.date.accessioned2020-12-14T06:25:41Z
dc.date.available2020-12-14T06:25:41Z
dc.date.issued2020-05-01
dc.identifier.citationWorthing, K. A., Werno, A., Pink, R., McIntyre, L., Carter, G. P., Williamson, D. A. & Davies, M. R. (2020). Biphasic Outbreak of Invasive Group A Streptococcus Disease in Eldercare Facility, New Zealand. EMERGING INFECTIOUS DISEASES, 26 (5), pp.841-848. https://doi.org/10.3201/eid2605.190131.
dc.identifier.issn1080-6040
dc.identifier.urihttp://hdl.handle.net/11343/254216
dc.description.abstractA 3-month outbreak of invasive group A Streptococcus disease at an eldercare facility, in which 5 persons died, was biphasic. Although targeted chemoprophylaxis contained the initial outbreak, a second phase of the outbreak occurred after infection control processes ended. To retrospectively investigate the genomic epidemiology of the biphasic outbreak, we used whole-genome sequencing and multiple bioinformatics approaches. Analysis of isolates from the outbreak and isolates prospectively collected during the outbreak response indicated a single S. pyogenes emm81 clone among residents and staff members. Outbreak isolates differed from nonoutbreak emm81 isolates by harboring an integrative conjugative genomic element that contained the macrolide resistance determinant erm(TR). This study shows how retrospective high-resolution genomic investigations identified rapid spread of a closed-facilty clonal outbreak that was controlled, but not readily cleared, by infection control management procedures.
dc.languageEnglish
dc.publisherCENTERS DISEASE CONTROL & PREVENTION
dc.titleBiphasic Outbreak of Invasive Group A Streptococcus Disease in Eldercare Facility, New Zealand
dc.typeJournal Article
dc.identifier.doi10.3201/eid2605.190131
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleEmerging Infectious Diseases
melbourne.source.volume26
melbourne.source.issue5
melbourne.source.pages841-848
melbourne.identifier.nhmrc1123854
melbourne.identifier.nhmrc1130455
melbourne.elementsid1448964
melbourne.openaccess.urlhttp://doi.org/10.3201/eid2605.190131
melbourne.openaccess.statusPublished version
melbourne.contributor.authorWilliamson, Deborah
melbourne.contributor.authorCarter, Glen
melbourne.contributor.authorDavies, Mark
melbourne.contributor.authorWorthing, Kate
melbourne.contributor.authorMcIntyre, Liam
dc.identifier.eissn1080-6059
melbourne.identifier.fundernameidNHMRC, 1123854
melbourne.identifier.fundernameidNHMRC, 1130455
melbourne.accessrightsAccess this item via the Open Access location


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