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dc.contributor.authorCoyle, L
dc.contributor.authorMorley, NJ
dc.contributor.authorRambaldi, A
dc.contributor.authorMason, KD
dc.contributor.authorVerhoef, G
dc.contributor.authorFurness, CL
dc.contributor.authorZhang, A
dc.contributor.authorJung, AS
dc.contributor.authorCohan, D
dc.contributor.authorFranklin, JL
dc.identifier.citationCoyle, L., Morley, N. J., Rambaldi, A., Mason, K. D., Verhoef, G., Furness, C. L., Zhang, A., Jung, A. S., Cohan, D. & Franklin, J. L. (2020). Open-Label, phase 2 study of blinatumomab as second salvage therapy in adults with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma. LEUKEMIA & LYMPHOMA, 61 (9), pp.2103-2112.
dc.description.abstractThe phase 2 portion of this open-label phase 2/3 study assessed the efficacy and safety of blinatumomab as second salvage for aggressive relapsed or refractory (r/r) aggressive B-cell non-Hodgkin lymphoma (B-NHL) following platinum-based first salvage chemotherapy. Forty-one patients with aggressive disease (32% relapsed; 68% refractory) enrolled and received stepwise blinatumomab (9-28-112 μg/day) in a 70-day cycle 1 and an optional 28-day cycle 2; 19 (46%) completed cycle 1 and 3 (7%) completed cycle 2. The overall response rate after 12 weeks was 37%, including 9 (22%) complete metabolic responses. Eight (20%) patients (all responders) subsequently received stem cell transplants. Grade ≥3 adverse events were reported in 29 (71%) patients. Grade 3 cytokine release syndrome occurred in one patient. Grade 3 neurologic events occurred in 10 (24%) patients; all resolved. Blinatumomab monotherapy appears effective as second salvage therapy in patients with r/r aggressive B-NHL. Trial registration: NCT02910063.
dc.publisherTAYLOR & FRANCIS LTD
dc.titleOpen-Label, phase 2 study of blinatumomab as second salvage therapy in adults with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma
dc.typeJournal Article
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleLeukemia and Lymphoma
melbourne.openaccess.statusPublished version
melbourne.contributor.authorMason, Kylie
melbourne.accessrightsAccess this item via the Open Access location

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