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  • Florey Department of Neuroscience and Mental Health
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    The pontine Kölliker-Fuse nucleus gates facial, hypoglossal, and vagal upper airway related motor activity.

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    Author
    Dutschmann, M; Bautista, TG; Trevizan-Baú, P; Dhingra, RR; Furuya, WI
    Date
    2021-02
    Source Title
    Respiratory Physiology and Neurobiology
    Publisher
    Elsevier BV
    University of Melbourne Author/s
    Dutschmann, Mathias
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Dutschmann, M., Bautista, T. G., Trevizan-Baú, P., Dhingra, R. R. & Furuya, W. I. (2021). The pontine Kölliker-Fuse nucleus gates facial, hypoglossal, and vagal upper airway related motor activity.. Respir Physiol Neurobiol, 284, pp.103563-. https://doi.org/10.1016/j.resp.2020.103563.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/254322
    DOI
    10.1016/j.resp.2020.103563
    Abstract
    The pontine Kölliker-Fuse nucleus (KFn) is a core nucleus of respiratory network that mediates the inspiratory-expiratory phase transition and gates eupneic motor discharges in the vagal and hypoglossal nerves. In the present study, we investigated whether the same KFn circuit may also gate motor activities that control the resistance of the nasal airway, which is of particular importance in rodents. To do so, we simultaneously recorded phrenic, facial, vagal and hypoglossal cranial nerve activity in an in situ perfused brainstem preparation before and after bilateral injection of the GABA-receptor agonist isoguvacine (50-70 nl, 10 mM) into the KFn (n = 11). Our results show that bilateral inhibition of the KFn triggers apneusis (prolonged inspiration) and abolished pre-inspiratory discharge of facial, vagal and hypoglossal nerves as well as post-inspiratory discharge in the vagus. We conclude that the KFn plays a critical role for the eupneic regulation of naso-pharyngeal airway patency and the potential functions of the KFn in regulating airway patency and orofacial behavior is discussed.

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