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dc.contributor.authorDutschmann, M
dc.contributor.authorBautista, TG
dc.contributor.authorTrevizan-Baú, P
dc.contributor.authorDhingra, RR
dc.contributor.authorFuruya, WI
dc.date.accessioned2020-12-15T22:58:07Z
dc.date.available2020-12-15T22:58:07Z
dc.date.issued2021-02
dc.identifierpii: S1569-9048(20)30221-4
dc.identifier.citationDutschmann, M., Bautista, T. G., Trevizan-Baú, P., Dhingra, R. R. & Furuya, W. I. (2021). The pontine Kölliker-Fuse nucleus gates facial, hypoglossal, and vagal upper airway related motor activity.. Respir Physiol Neurobiol, 284, pp.103563-. https://doi.org/10.1016/j.resp.2020.103563.
dc.identifier.issn1569-9048
dc.identifier.urihttp://hdl.handle.net/11343/254322
dc.description.abstractThe pontine Kölliker-Fuse nucleus (KFn) is a core nucleus of respiratory network that mediates the inspiratory-expiratory phase transition and gates eupneic motor discharges in the vagal and hypoglossal nerves. In the present study, we investigated whether the same KFn circuit may also gate motor activities that control the resistance of the nasal airway, which is of particular importance in rodents. To do so, we simultaneously recorded phrenic, facial, vagal and hypoglossal cranial nerve activity in an in situ perfused brainstem preparation before and after bilateral injection of the GABA-receptor agonist isoguvacine (50-70 nl, 10 mM) into the KFn (n = 11). Our results show that bilateral inhibition of the KFn triggers apneusis (prolonged inspiration) and abolished pre-inspiratory discharge of facial, vagal and hypoglossal nerves as well as post-inspiratory discharge in the vagus. We conclude that the KFn plays a critical role for the eupneic regulation of naso-pharyngeal airway patency and the potential functions of the KFn in regulating airway patency and orofacial behavior is discussed.
dc.languageeng
dc.publisherElsevier BV
dc.titleThe pontine Kölliker-Fuse nucleus gates facial, hypoglossal, and vagal upper airway related motor activity.
dc.typeJournal Article
dc.identifier.doi10.1016/j.resp.2020.103563
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleRespiratory Physiology and Neurobiology
melbourne.source.volume284
melbourne.source.pages103563-
melbourne.elementsid1469594
melbourne.contributor.authorDutschmann, Mathias
dc.identifier.eissn1878-1519
melbourne.accessrightsThis item is currently not available from this repository


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